Evidence map›Paper›PMID 42032403›Full record

ArticleBulletin of experimental biology and medicine2026

Application of a Three-Cell Blood-Brain Barrier Model to Assess Neurovascular Unit Cell Damage in Alzheimer's Disease.

N A Rozanova, A S Averchuk, M R Kapkaeva, V I Zhdankina, V I Makarov, A S Skobeltsin, I D Romanishkin, T I Baranich, A B Salmina

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Article in Bulletin of experimental biology and medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

N A RozanovaRussian Center of Neurology and Neurosciences, Moscow, Russia.
A S AverchukRussian Center of Neurology and Neurosciences, Moscow, Russia.
M R KapkaevaRussian Center of Neurology and Neurosciences, Moscow, Russia.
V I ZhdankinaRussian Center of Neurology and Neurosciences, Moscow, Russia.
V I MakarovRussian Center of Neurology and Neurosciences, Moscow, Russia.
A S SkobeltsinNational Research Nuclear University MEPhI (Moscow Engineering Physics Institute), Moscow, Russia.
I D RomanishkinProkhorov General Physics Institute, Russian Academy of Sciences, Moscow, Russia.
T I BaranichRussian Center of Neurology and Neurosciences, Moscow, Russia. baranich_tatyana@mail.ru.
A B SalminaRussian Center of Neurology and Neurosciences, Moscow, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To assess functional characteristics of cells of the neurovascular unit in Alzheimer's disease (AD), we performed differentiation of induced pluripotent stem cells from an AD patient (Alz9L cell line) into neuronal, glial, and endothelial cells with the formation of a three-cell model of the blood-brain barrier (BBB). Increased BBB permeability combined with changes in synaptic plasticity of neurons and changes in the metabolism of endothelial cells was detected in AD. The obtained results confirm the presence of vascular dysfunction during AD development and indicate the possibility of using personalized BBB models to assess the features of barrier formation.

Indexed as

Alzheimer DiseaseBlood-Brain BarrierCell DifferentiationCell LineEndothelial CellsHumansInduced Pluripotent Stem CellsNeurogliaNeuronal PlasticityNeuronsAlzheimer’s diseaseBBBendotheliumneuronTranswell model

Identifiers

PMID42032403

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.