ArticleBulletin of experimental biology and medicine2026
Effect of Imperatorin on Apoptosis of Myocardial Tissue in Diabetic Rats.
Article in Bulletin of experimental biology and medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Diabetic cardiomyopathy (DCM) represents a significant complication of diabetes, with a considerable number of deaths attributed to DCM on an annual global basis. We investigated the role and mechanism of action of imperatorin in the prevention and treatment of DCM using a diabetic rat model. The results of animal experiments showed that diabetic rats treated with imperatorin had lower levels of lactate dehydrogenase, aspartate aminotransferase, and creatine kinase MB isoenzyme, lower heart/body weight ratio, less pronounced histopathological changes in the myocardium, reduced expression of Caspase-3 and Bax, and increased expression of Bcl-2. Thus, imperatorin could attenuate pathological damage in diabetic myocardial tissue, which may be attributed to its regulatory effects on apoptosis.
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