Evidence map›Paper›PMID 42032394›Full record

ArticleCanadian journal of anaesthesia = Journal canadien d'anesthesie2026

Differential effects of phenylephrine on brain versus skeletal muscle microvascular perfusion: an in vivo laboratory study using translational rodent models.

Helen Jiang, Kyle Chin, Timothy H Mak, S F Michelle Ku, Sami I Alissa, Albert K Y Tsui, Elaine Liu, Nikhil Mistry, Talin Boghosian T, Sebastian Swic and 9 more

Abstract read
PubMed Publisher
In one paragraph

Article in Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Helen JiangDepartment of Anesthesiology & Pain Medicine, University of Toronto, Toronto, ON, Canada.
Kyle ChinDepartment of Anesthesiology & Pain Medicine, University of Toronto, Toronto, ON, Canada.
Timothy H MakDepartment of Anesthesiology & Pain Medicine, University of Toronto, Toronto, ON, Canada.
S F Michelle KuDepartment of Anesthesiology & Pain Medicine, University of Toronto, Toronto, ON, Canada.
Sami I AlissaDivision of Plastic and Reconstructive Surgery, Department of Surgery, University of Toronto, Toronto, ON, Canada.
Albert K Y TsuiDepartment of Anesthesiology & Pain Medicine, University of Toronto, Toronto, ON, Canada.
Elaine LiuDepartment of Anesthesiology & Pain Medicine, University of Toronto, Toronto, ON, Canada.
Nikhil MistryDepartment of Anesthesiology & Pain Medicine, University of Toronto, Toronto, ON, Canada.
Talin Boghosian TLibrary Services Unity Health Toronto, St. Michael's Hospital, Toronto, ON, Canada.
Sebastian SwicDepartment of Anesthesiology & Pain Medicine, University of Toronto, Toronto, ON, Canada.
David F WilsonDepartment of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA, USA.
Sergei A VinogradovDepartment of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA, USA.
James L MahoneyDivision of Plastic and Reconstructive Surgery, Department of Surgery, University of Toronto, Toronto, ON, Canada.
Bijan TejaDepartment of Anesthesiology & Pain Medicine, University of Toronto, Toronto, ON, Canada.
Ahmad AlliDepartment of Anesthesiology & Pain Medicine, University of Toronto, Toronto, ON, Canada.
Andrew J BakerDepartment of Anesthesiology & Pain Medicine, University of Toronto, Toronto, ON, Canada.
C David MazerDepartment of Anesthesiology & Pain Medicine, University of Toronto, Toronto, ON, Canada.
Gregory M T HareDepartment of Anesthesiology & Pain Medicine, University of Toronto, Toronto, ON, Canada. greg.hare@unityhealth.to.ORCID 0000-0003-4641-4818
Melinda A MusgraveDivision of Plastic and Reconstructive Surgery, Department of Surgery, University of Toronto, Toronto, ON, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeHypotension, or low mean arterial blood pressure (MAP), has been associated with adverse outcomes in perioperative patients. A primary goal of treating hypotension during surgery is to preserve vital organ perfusion by maintaining intravascular volume and the use of vasoactive medications, including phenylephrine (PE), to support MAP. Phenylephrine, a vasoconstrictor with α

methodsWe conducted an in vivo animal study using translational rodent models. Measuring microvascular blood flow (laser Doppler) and partial pressure of oxygen (PO

resultsTreatment of hypotension with PE increased MAP, brain microvascular blood flow, and brain tissue PO

conclusionsThese data may inform the optimal use of PE to restore MAP to ensure optimal brain tissue perfusion. Use of tissue oximetry may ensure the adequacy of tissue perfusion in perioperative patients.

Indexed as

BrainMuscle, SkeletalPhenylephrineVasoconstrictor AgentsAnimalsHypotensionLaser-Doppler FlowmetryMaleMicrocirculationOxygenRatsRats, Sprague-DawleyRegional Blood FlowSurgical FlapsOxygenPhenylephrineVasoconstrictor Agentsanimal modelsblood pressure supportcerebral perfusionhypotensionphenylephrine

Identifiers

PMID42032394

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.