Evidence map›Paper›PMID 42032339›Full record

ArticleInternational journal of obesity (2005)2026

Bariatric surgery and subsequent weight loss lead to a reversal of peripheral blood monocytosis in obesity.

Marco Krasselt, Kathleen Friedrich, Laurin Braune, Kathrin Rothe, Matthias Blüher, Peter Kovacs, Arne Dietrich, Manuela Rossol, Michael Stumvoll, Ulf Wagner

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of obesity (2005), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Marco Krasselt *Rheumatology, Medical Clinic III: Endocrinology, Nephrology and Rheumatology, Department of Internal Medicine, Neurology and Dermatology, University of Leipzig Medical Centre, Liebigstr. 20, 04103, Leipzig, Germany. marco.krasselt@medizin.uni-leipzig.de.ORCID http://orcid.org/0000-0002-1842-0754
Kathleen Friedrich *Rheumatology, Medical Clinic III: Endocrinology, Nephrology and Rheumatology, Department of Internal Medicine, Neurology and Dermatology, University of Leipzig Medical Centre, Liebigstr. 20, 04103, Leipzig, Germany.
Laurin BrauneRheumatology, Medical Clinic III: Endocrinology, Nephrology and Rheumatology, Department of Internal Medicine, Neurology and Dermatology, University of Leipzig Medical Centre, Liebigstr. 20, 04103, Leipzig, Germany.
Kathrin RotheRheumatology, Medical Clinic III: Endocrinology, Nephrology and Rheumatology, Department of Internal Medicine, Neurology and Dermatology, University of Leipzig Medical Centre, Liebigstr. 20, 04103, Leipzig, Germany.
Matthias BlüherEndocrinology, Medical Clinic III: Endocrinology, Nephrology and Rheumatology, Department of Internal Medicine, Neurology and Dermatology, University of Leipzig Medical Centre, Liebigstr. 20, 04103, Leipzig, Germany.ORCID http://orcid.org/0000-0003-0208-2065
Peter KovacsEndocrinology, Medical Clinic III: Endocrinology, Nephrology and Rheumatology, Department of Internal Medicine, Neurology and Dermatology, University of Leipzig Medical Centre, Liebigstr. 20, 04103, Leipzig, Germany.ORCID http://orcid.org/0000-0002-0290-5423
Arne DietrichDepartment of Visceral, Transplant, Thoracic and Vascular Surgery, University of Leipzig Medical Centre, Liebigstr. 20, 04103, Leipzig, Germany.
Manuela RossolMolecular Immunology, Brandenburg University of Technology, Universitätsplatz 1, 01968, Senftenberg, Germany.
Michael StumvollEndocrinology, Medical Clinic III: Endocrinology, Nephrology and Rheumatology, Department of Internal Medicine, Neurology and Dermatology, University of Leipzig Medical Centre, Liebigstr. 20, 04103, Leipzig, Germany.ORCID http://orcid.org/0000-0001-6225-8240
Ulf WagnerRheumatology, Medical Clinic III: Endocrinology, Nephrology and Rheumatology, Department of Internal Medicine, Neurology and Dermatology, University of Leipzig Medical Centre, Liebigstr. 20, 04103, Leipzig, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo examine changes in monocyte subpopulations and surface markers in people with obesity before and after bariatric surgery, and their relation to weight loss, inflammation markers, and comorbidities.

methodsPeripheral blood mononuclear cells (PBMCs) were isolated from patients with obesity designated for bariatric surgery at three different time points: before surgery (=baseline), six months and twelve months after the intervention. PBMCs were analyzed using flow cytometry to distinguish the different monocytic subpopulations. At each visit, anthropometric measures and routine laboratory parameters (e.g., C-reactive protein) have been determined.

results111 individuals with obesity (59.5% female, mean age 45.2±11.3 years) with a median body mass index (BMI) of 48.4 kg/m

conclusionsFollowing bariatric surgery and the resulting weight loss, the obesity-associated perturbation of the monocyte compartment was largely reversed. Normalization of both the total monocyte pool and of monocyte subpopulations, particularly those with pro-inflammatory properties such as intermediate monocytes, could contribute to a risk reduction of known co-morbidities of obesity such as chronic inflammation, impaired glucose regulation, and an increased risk of cancer.

Indexed as

Bariatric SurgeryMonocytesObesityObesity, MorbidWeight LossAdultBiomarkersBody Mass IndexFemaleFlow CytometryHumansMaleMiddle AgedBiomarkers

Identifiers

PMID42032339
PMCPMC13461359

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.