Evidence map›Paper›PMID 42032323›Full record

Reviewnpj biomedical innovations2026

Engineering macrophages for cancer immunotherapy: emerging insights and therapeutic potential.

Anton Block, Xiaoya Liu, Daniel Zhang, Kolade Adebowale

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in npj biomedical innovations, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Microneedle-Assisted Cell Delivery and Therapy.Research (Washington, D.C.) · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Anton Block *Shu Chien-Gene Lay Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA.
Xiaoya Liu *Shu Chien-Gene Lay Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA.
Daniel Zhang *Shu Chien-Gene Lay Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA.
Kolade AdebowaleShu Chien-Gene Lay Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA. kadebowale@ucsd.edu.

Funding

UC San Diego FIRST ProgramU54CA272220 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MARIA ELENA MARTINEZ, Joann Trejo · 2022 to 2026
$21.2M
NCI NIH HHS U54 CA272220
6 · The paper itself

Abstract

Macrophages strongly influence cancer progression through their adaptable phenotypes and responses to mechanical and biochemical cues. Their abundance across tumors and links to poor outcomes drive interest in macrophage-targeted therapies. This review highlights macrophage mechanobiology, key behaviors, and the potential of engineered macrophages, using genetic (CAR) or non-genetic "Trojan horse" and "backpacking" strategies, to deliver therapies and reshape the immunosuppressive tumor microenvironment.

Identifiers

PMID42032323
PMCPMC13055078

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.