Articlenpj biomedical innovations2025
Bioengineered articular cartilage biomimetic organ-on-a-chip using microfluidics.
Article in npj biomedical innovations, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Bioinspired and smart material systems for auricular cartilage engineering: toward microenvironment-responsive and self-regulating scaffolds.Regenerative biomaterials · 2026Review
- Organ-on-chip technologies: Novel tools with the potential to revolutionize osteoarthritis research and clinical development.Osteoarthritis and cartilage open · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Cartilage tissue engineering is complex owing to the apt choice of biopolymers, cell source and dynamic simulation. Herein, we elucidate a novel approach to mesenchymal stem cells (MSCs)- induced chondrogenesis using microfluidics on an organ-on-a-chip (OOAC) model, coupled with decellularized extracellular matrix (dECM) as bioink additive, on optimised composite hydrogel. The hydrogel displayed a compression modulus of 0.18 MPa and tensile strength of 0.4 MPa. Microfluidic shear pressures of 150 mbar and 50 mbar were optimised to attain the superficial and middle zones respectively, with a media flow rate of 5 µL min
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.