Evidence map›Paper›PMID 42032311›Full record

ArticleNature cell biology2026

Electrophilic compound screening identifies GPX4-dependent ferroptosis as a senescence vulnerability.

Mariantonietta D'Ambrosio, Matthew E H White, Efthymios S Gavriil, Laura Bousset, Jodie Birch, Aleksandra Gruevska, Emiliano Pasquini, Manuel Colucci, Winnie Fong, Simone Mosole and 24 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature cell biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors.

Mariantonietta D'AmbrosioMRC Laboratory of Medical Sciences, Du Cane Road, London, UK.
Matthew E H WhiteMRC Laboratory of Medical Sciences, Du Cane Road, London, UK.
Efthymios S GavriilDepartment of Chemistry, Molecular Sciences Research Hub, Imperial College London, London, UK.
Laura BoussetMRC Laboratory of Medical Sciences, Du Cane Road, London, UK.ORCID http://orcid.org/0000-0002-5339-3173
Jodie BirchMRC Laboratory of Medical Sciences, Du Cane Road, London, UK.
Aleksandra GruevskaDepartment of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.
Emiliano PasquiniInstitute of Oncology Research, Bellinzona, Switzerland.
Manuel ColucciInstitute of Oncology Research, Bellinzona, Switzerland.ORCID http://orcid.org/0000-0002-4955-5416
Winnie FongUniversity of Tübingen, Faculty of Medicine, Institute for Interdisciplinary Research on Cancer Metabolism and Chronic Inflammation, M3 Research Center for Malignome, Metabolome and Microbiome, Tübingen, Germany.
Simone MosoleInstitute of Oncology Research, Bellinzona, Switzerland.
Aurora ValdataInstitute of Oncology Research, Bellinzona, Switzerland.
Dimitris VeroutisDivision of Cancer Research, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK.
Katie TysonOvarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK.ORCID http://orcid.org/0009-0007-0339-514X
Vikas RanvirGerman Cancer Research Center, Division of Chronic Inflammation and Cancer, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-0437-6908
Sandra ProkoschGerman Cancer Research Center, Division of Chronic Inflammation and Cancer, Heidelberg, Germany.
Joaquim PomboMRC Laboratory of Medical Sciences, Du Cane Road, London, UK.
Aoki ArdissonDepartment of Chemistry, Molecular Sciences Research Hub, Imperial College London, London, UK.
Sanjay KhadayateMRC Laboratory of Medical Sciences, Du Cane Road, London, UK.ORCID http://orcid.org/0000-0003-4278-6403
George YoungMRC Laboratory of Medical Sciences, Du Cane Road, London, UK.ORCID http://orcid.org/0000-0002-1203-588X
Alex MontoyaMRC Laboratory of Medical Sciences, Du Cane Road, London, UK.
Georgia RoumeliotiMRC Laboratory of Medical Sciences, Du Cane Road, London, UK.
Jack HoughtonDepartment of Chemistry, Molecular Sciences Research Hub, Imperial College London, London, UK.
Jianan LuDepartment of Chemistry, Molecular Sciences Research Hub, Imperial College London, London, UK.
Pavel V ShliahaMRC Laboratory of Medical Sciences, Du Cane Road, London, UK.
Elena De VitaDepartment of Chemistry, Molecular Sciences Research Hub, Imperial College London, London, UK.
Santiago VerniaMRC Laboratory of Medical Sciences, Du Cane Road, London, UK.ORCID http://orcid.org/0000-0001-6728-5555
Vassilis G GorgoulisDivision of Cancer Research, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK.
Suchira GallageUniversity of Tübingen, Faculty of Medicine, Institute for Interdisciplinary Research on Cancer Metabolism and Chronic Inflammation, M3 Research Center for Malignome, Metabolome and Microbiome, Tübingen, Germany.
Mathias HeikenwälderUniversity of Tübingen, Faculty of Medicine, Institute for Interdisciplinary Research on Cancer Metabolism and Chronic Inflammation, M3 Research Center for Malignome, Metabolome and Microbiome, Tübingen, Germany.
Zoe HallDepartment of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.
Andrea AlimontiInstitute of Oncology Research, Bellinzona, Switzerland.ORCID http://orcid.org/0000-0002-9362-2313
Iain A McNeishOvarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK.ORCID http://orcid.org/0000-0002-9387-7586
Edward W TateDepartment of Chemistry, Molecular Sciences Research Hub, Imperial College London, London, UK.ORCID http://orcid.org/0000-0003-2213-5814
Jesús GilMRC Laboratory of Medical Sciences, Du Cane Road, London, UK. jesus.gil@imperial.ac.uk.ORCID http://orcid.org/0000-0002-4303-6260

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Senescent cells drive ageing and age-related pathologies, including cancer. Consequently, senolytics, drugs that selectively kill senescent cells, have broad therapeutic appeal. Here we report a senolytic screen of a library of 10,480 electrophilic compounds. Among 38 identified hits, we found a subset of chloroacetamides with broad senolytic activity. Activity-based protein profiling, coupled with functional assays, identified the glutathione peroxidase GPX4 as a target. We show that senescent cells are primed for ferroptosis, displaying high levels of oxidative stress and intracellular Fe

Indexed as

Antineoplastic AgentsCellular SenescenceFerroptosisPhospholipid Hydroperoxide Glutathione PeroxidaseSenotherapeuticsAnimalsCell Line, TumorEnzyme InhibitorsGlutathione PeroxidaseHumansOxidative StressAntineoplastic AgentsEnzyme InhibitorsGlutathione PeroxidasePhospholipid Hydroperoxide Glutathione PeroxidaseSenotherapeutics

Identifiers

PMID42032311
PMCPMC13179136

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.