Evidence map›Paper›PMID 42032302›Full record

ArticleNature immunology2026

A spatially coordinated keratinocyte-fibroblast circuit recruits MMP9

Yuqing Wang, Khashayar Afshari, Nazgol-Sadat Haddadi, Carolina Salomão Lopes, Chee-Huat Linus Eng, Leah M Whiteman, Nuria Martinez, Pyae P Kyawe, Ksenia S Anufrieva, Kevin Wei and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Yuqing Wang *Department of Genomics and Computational Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Khashayar Afshari *Department of Dermatology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Nazgol-Sadat Haddadi *Department of Dermatology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Carolina Salomão LopesDepartment of Genomics and Computational Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Chee-Huat Linus EngSpatial Genomics, Pasadena, CA, USA.
Leah M WhitemanDivision of Innate Immunity, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID http://orcid.org/0009-0001-2297-5998
Nuria MartinezDepartment of Dermatology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Pyae P KyaweDepartment of Dermatology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Ksenia S AnufrievaDivision of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital at Harvard Medical School, Boston, MA, USA.
Kevin WeiDivision of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital at Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-1821-167X
Kirsten FriedaSpatial Genomics, Pasadena, CA, USA.
Misha RosenbachDepartment of Dermatology, University of Pennsylvania, Philadelphia, PA, USA.
Ruth Ann VleugelsDepartment of Dermatology, Brigham and Women's Hospital at Harvard Medical School, Boston, MA, USA.
Stefania GallucciDivision of Innate Immunity, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID http://orcid.org/0000-0003-4737-8003
John E HarrisDepartment of Dermatology, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID http://orcid.org/0000-0002-7815-6430
Mehdi RashighiDepartment of Dermatology, University of Massachusetts Chan Medical School, Worcester, MA, USA. mehdi.rashighi@umassmed.edu.ORCID http://orcid.org/0000-0002-9170-5887
Manuel GarberDepartment of Genomics and Computational Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA. manuel.garber@umassmed.edu.ORCID http://orcid.org/0000-0001-8732-1293

Funding

P50-Admin Core-Harris/GarbP50AR080593 · NIAMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI John E Harris · 2022 to 2026
$9.2M
Predictive drivers of new onset, relapse, and progression of human autoimmunity in skinU01AI176310 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Manuel Garber, John E Harris · 2023 to 2026
$5.3M
Parsing cholesterol metabolite regulation of skin immunocytes in children to identify archetypes of human neonatal immune systemU01AI168640 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Joonsoo Kang, Mehdi Rashighi · 2022 to 2026
$4.1M
Interrogating Clonal Repertoire in Drug Hypersensitivity ReactionsR01AI181221 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI Sherrie Jill Divito, Manuel Garber · 2024 to 2026
$2.6M
Pathogenic fibroblast differentiation in rheumatoid arthritisK08AR077037 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI WEI, KEVIN S · 2020 to 2024
$799k
Division of Intramural Research, National Institute of Allergy and Infectious Diseases (Division of Intramural Research of the NIAID) 5U01AI176310NIAID NIH HHS R01 AI181221NIAID NIH HHS U01 AI168640NIAID NIH HHS U01 AI176310NIAMS NIH HHS K08 AR077037NIAMS NIH HHS P50 AR080593U.S. Department of Health & Human Services | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) K08AR077037U.S. Department of Health & Human Services | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) P50AR080593
6 · The paper itself

Abstract

Photosensitivity is central to cutaneous lupus erythematosus and dermatomyositis (DM), but the mechanisms linking UVB exposure to tissue-specific autoimmunity are poorly defined. Using single-cell RNA sequencing, spatial transcriptomics, proteomics, UVB provocation and in vitro modeling, we identify MMP9

Indexed as

AutoimmunityFibroblastsInterferon Type IKeratinocytesMatrix Metalloproteinase 9Myeloid CellsPhotosensitivity DisordersAnimalsCells, CulturedDermatomyositisFemaleHumansInflammationMiceSkinUltraviolet RaysInterferon Type IMatrix Metalloproteinase 9MMP9 protein, human

Identifiers

PMID42032302
PMCPMC13226071

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.