Evidence map›Paper›PMID 42032258›Full record

ArticleScientific reports2026

Physician burnout and type D personality relate to pericoronary fat phenotype and role of sympathetic activation: a cross-sectional study.

Roland von Känel, Tobia Albertini, Sarah A Holzgang, Mary Princip, Andreas A Giannopoulos, Ronny R Buechel, Daniel J de Wilde, Sinthujan Sivakumar, Claudia Zuccarella-Hackl, Aju P Pazhenkottil

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Roland von KänelDepartment of Consultation-Liaison Psychiatry and Psychosomatic Medicine, University Hospital Zurich, University of Zurich, Haldenbachstrasse 16/18, 8091, Zurich, Switzerland. roland.vonkaenel@usz.ch.
Tobia AlbertiniCardiac Imaging, Department of Nuclear Medicine, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Sarah A HolzgangDepartment of Consultation-Liaison Psychiatry and Psychosomatic Medicine, University Hospital Zurich, University of Zurich, Haldenbachstrasse 16/18, 8091, Zurich, Switzerland.
Mary PrincipDepartment of Consultation-Liaison Psychiatry and Psychosomatic Medicine, University Hospital Zurich, University of Zurich, Haldenbachstrasse 16/18, 8091, Zurich, Switzerland.
Andreas A GiannopoulosCardiac Imaging, Department of Nuclear Medicine, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Ronny R BuechelCardiac Imaging, Department of Nuclear Medicine, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Daniel J de WildeCardiac Imaging, Department of Nuclear Medicine, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Sinthujan SivakumarDepartment of Consultation-Liaison Psychiatry and Psychosomatic Medicine, University Hospital Zurich, University of Zurich, Haldenbachstrasse 16/18, 8091, Zurich, Switzerland.
Claudia Zuccarella-HacklDepartment of Consultation-Liaison Psychiatry and Psychosomatic Medicine, University Hospital Zurich, University of Zurich, Haldenbachstrasse 16/18, 8091, Zurich, Switzerland.
Aju P PazhenkottilDepartment of Consultation-Liaison Psychiatry and Psychosomatic Medicine, University Hospital Zurich, University of Zurich, Haldenbachstrasse 16/18, 8091, Zurich, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biological pathways linking psychosocial stress to coronary pathology remain elusive. Burnout and type D personality (TDP), defined by negative affectivity and social inhibition, are prevalent among physicians and associated with cardiovascular risk. We investigated whether burnout and TDP relate to pericoronary adipose tissue (PCAT) attenuation, a noninvasive imaging marker of fat composition and coronary inflammatory signaling. We further investigated whether sympathetic activation is implicated as an indirect pathway in this association. Systemic inflammation was examined as a downstream correlate. Sixty male physicians (30 with burnout, 30 controls) underwent coronary computed tomography angiography and cold pressor testing to assess PCAT attenuation and peak rate pressure product (RPP) as a measure of sympathetic activation. Burnout and TDP traits were measured using validated questionnaires. Regression models tested associations among burnout, negative affectivity-by-social inhibition interaction, peak RPP, PCAT attenuation, and high-sensitivity C-reactive protein. Burnout was associated with lower PCAT attenuation after adjustment for TDP and cardiovascular risk factors (- 3.79 Hounsfield units, 95% CI: - 7.55, - 0.029; p = 0.048; ΔR

Indexed as

Burnout, ProfessionalEpicardial Adipose TissueSympathetic Nervous SystemType D PersonalityComputed Tomography AngiographyCross-Sectional StudiesHumansMalePhenotypeStress, PsychologicalAutonomic nervous systemCoronary artery diseaseInflammationPerivascular adipose tissueProfessional burnoutType D personality

Identifiers

PMID42032258
PMCPMC13275879

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.