ArticleAnnals of hematology2026
Renal complications in pediatric sickle cell disease: results from a single-center study.
Article in Annals of hematology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sickle cell disease (SCD), caused by a mutation in the β-globin gene, leads to acute hemolytic crises and chronic anemia, necessitating frequent blood transfusions. Renal involvement begins early in life and is multifactorial. Chronic kidney disease (CKD) develops in about 30% of SCD adults and is a major cause of death. This study aims to identify markers of glomerular and tubular damage, along with potential risk factors, in a pediatric SCD cohort. We conducted monthly blood and urine tests over 24 months on pediatric patients with SCD. Glomerular hyperfiltration was defined as an estimated glomerular filtration rate (eGFR) > 140 ml/min/1.73 m², while CKD was defined as either eGFR < 60 ml/min/1.73 m² or the presence of specific structural or functional abnormalities. Proteinuria was measured by urinary albumin–creatinine ratio (uACR) or urinary protein-creatinine ratio (UPCR). The study enrolled 46 pediatric SCD patients with a median age of 12 years (range 3–18 years). Glomerular hyperfiltration was observed in 82.6% of patients. uACR and elevated UPCR were found in 15.2% and 32.6% of patients, respectively. A high transfusion requirement correlated with glomerular hyperfiltration and UPCR, irrespective of age. A significant portion of the cohort exhibited glomerular hyperfiltration and proteinuria, particularly those with high transfusion needs. These changes were observed independently of age, more as a consequence of disease progression over time, suggesting the need for early evaluation and potential treatment to prevent disease progression even at an early stage.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.