ReviewReproductive sciences (Thousand Oaks, Calif.)2026
Decoding Infertility: the Epigenetic Influence of HDACs on Reproductive Function.
Review in Reproductive sciences (Thousand Oaks, Calif.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
- Erratum issued
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Infertility is a multifactorial condition affecting approximately 10-15% of couples worldwide, with both male and female factors contributing equally. Among the emerging determinants of infertility are epigenetic regulators, particularly histone deacetylases, which modify chromatin structure and influence gene expression by removing acetyl groups from histone tails. Their dysregulation alters gene expression profiles critical for reproductive function. HDACs are classified into four major classes (I-IV) on the basis of their structure and function. A thorough analysis of previous research using animal models, clinical settings, and experiments was performed to investigate how HDACs function in gametogenesis, hormone regulation, and embryonic development, among other areas of reproductive physiology. HDACs play a key role in the epigenetic control of fertility in both sexes. Understanding their isoform-specific functions could help create more focused treatments for infertility and increase the success of reproduction. This review elucidates the mechanisms by which HDACs contribute to infertility and explores their potential as therapeutic targets in reproductive medicine.
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