Articlenpj biomedical innovations2025
Subcellular systems follow Onsager reciprocity.
Article in npj biomedical innovations, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
The complexity of prokaryotic and, exceedingly, of eukaryotic cells, challenges the implementation of methodologies to quantify intracellular dynamics. Although stochastic thermodynamics can effectively quantify the energetics of single proteins or complexes, there is no statistical approach to determine the macrostate of a whole cell from its subcellular microstates. The objective of this study is to test if Onsager reciprocity, a coupling between thermodynamic flows, occurs between time-dependent intracellular processes based on their measurements in previous studies. A prototypical thermodynamic profile of the cell is formulated as a model system to enable representation of its sub systems as force-driven thermodynamic flows. Onsager reciprocity is validated on the bacterial flagellum and ATP synthase. It is then tested on the putative coupling between the contractile ring and treadmilling of the cytoskeleton in bacterial binary fission and eukaryotic cytokinesis, with opposite outcomes. All thermodynamic flows and forces are formulated to comply with their canonical definitions.
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