Evidence map›Paper›PMID 42032188›Full record

ArticlePediatric research2026

Perioperative biventricular function in congenital diaphragmatic hernia: a three-dimensional echocardiographic study.

Katsuaki Toyoshima, Tomoko Saito, Kaoru Katsumata, Tomoyuki Shimokaze, Makoto Kishigami, Sasagu Kimura, Hirosato Aoki, Junya Ohmura, Jun Shibasaki, Motoyoshi Kawataki and 4 more

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Article in Pediatric research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

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1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

14 authors.

Katsuaki ToyoshimaDepartment of Neonatology, Kanagawa Children's Medical Center, Yokohama, Japan. NQF37179@nifty.com.
Tomoko SaitoDepartment of Neonatology, Kanagawa Children's Medical Center, Yokohama, Japan.
Kaoru KatsumataDepartment of Neonatology, Kanagawa Children's Medical Center, Yokohama, Japan.
Tomoyuki ShimokazeDepartment of Neonatology, Kanagawa Children's Medical Center, Yokohama, Japan.
Makoto KishigamiDepartment of Neonatology, Kanagawa Children's Medical Center, Yokohama, Japan.
Sasagu KimuraDepartment of Neonatology, Kanagawa Children's Medical Center, Yokohama, Japan.
Hirosato AokiDepartment of Neonatology, Kanagawa Children's Medical Center, Yokohama, Japan.
Junya OhmuraDepartment of Neonatology, Kanagawa Children's Medical Center, Yokohama, Japan.
Jun ShibasakiDepartment of Neonatology, Kanagawa Children's Medical Center, Yokohama, Japan.
Motoyoshi KawatakiDepartment of Neonatology, Kanagawa Children's Medical Center, Yokohama, Japan.
Kyoko MochizukiDepartment of Surgery, Kanagawa Children's Medical Center, Yokohama, Japan.
Norihiko KitagawaDepartment of Surgery, Kanagawa Children's Medical Center, Yokohama, Japan.
Naka SaitoDepartment of Clinical Laboratory, Kanagawa Children's Medical Center, Yokohama, Japan.
Satoshi MasutaniDepartment of Pediatrics, Saitama Medical University, Kawagoe, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCardiac dysfunction is increasingly recognized as an important feature in congenital diaphragmatic hernia (CDH); however, detailed longitudinal data describing perioperative biventricular adaptation remain limited.

methodsThis single-center retrospective study included 49 infants who underwent CDH surgery between 2017 and 2024. Three-dimensional echocardiography was used to measure left ventricular (LV) and right ventricular (RV) end-diastolic volume (LVEDV and RVEDV, respectively), ejection fraction (EF), and cardiac output at 1-3 days of age, preoperatively, and at <18 h and 24-72 h postoperatively.

resultsAt 1-3 days of age, LV parameters showed minimal changes. RVEF increased (37.5% to 45.5%; P < 0.001), with reductions in RV end-systolic volume and improved ventricular-arterial coupling. The LVEDV/RVEDV ratio increased from 0.65 ± 0.18 (1 day of age) to 0.74 ± 0.24 (preoperatively) (P = 0.001). Postoperatively (24-72 h), indexed ventricular and stroke volumes increased compared with preoperative measurements; LVEDV increased from 1.32 mL/kg to 1.51 mL/kg (P = 0.008) and RVEDV from 1.82 mL/kg to 2.07 mL/kg (P = 0.013).

conclusionPreoperatively, RV systolic performance and RV-pulmonary arterial coupling improved, possibly reflecting the effects of management and/or physiological adaptation. After repair, biventricular end-diastolic and stroke volumes increased, consistent with enhanced postoperative ventricular filling. IMPACT: This study is the first to serially evaluate biventricular volumes and function from birth through the perioperative period in infants with congenital diaphragmatic hernia (CDH) using three-dimensional echocardiography. Preoperatively, right ventricular-pulmonary arterial coupling improved over time. Surgical repair was associated with increases in biventricular end-diastolic volumes and stroke volumes in the early postoperative phase, consistent with enhanced ventricular filling. This study provides novel physiological insights into the distinct adaptive mechanisms of both ventricles, which may have valuable implications for perioperative management.

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PMID42032188

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