CcAbl1 is required for virulence via regulating NADPH-glutathione-mediated redox balance in Cytospora chrysosperma.

Wenjun Song, Ruifeng Guo, Jia Zhou, Yonglin Wang

Abstract read

In one paragraph

Article in Stress biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

4 authors.

Wenjun SongState Key Laboratory of Efficient Production of Forest Resources, Beijing Key Laboratory for Forest Pest Control, College of Forestry, Beijing Forestry University, Beijing, 100083, China.

Ruifeng GuoState Key Laboratory of Efficient Production of Forest Resources, Beijing Key Laboratory for Forest Pest Control, College of Forestry, Beijing Forestry University, Beijing, 100083, China.

Jia ZhouState Key Laboratory of Efficient Production of Forest Resources, Beijing Key Laboratory for Forest Pest Control, College of Forestry, Beijing Forestry University, Beijing, 100083, China.

Yonglin WangState Key Laboratory of Efficient Production of Forest Resources, Beijing Key Laboratory for Forest Pest Control, College of Forestry, Beijing Forestry University, Beijing, 100083, China. ylwang@bjfu.edu.cn.ORCID http://orcid.org/0000-0003-0993-8102

Funding

Fundamental Research Funds for the Central Universities QNTD202510National Key R&D Program of China 2022YFD1401000

6 · The paper itself

Abstract

To counteract the reactive oxygen species (ROS) derived from host plants, pathogenic fungi employ various strategies to overcome ROS or balance redox homeostasis. Glucose metabolism is vital for fungi and provides NADPH for antioxidation, but the molecular features linking glucose metabolism and redox homeostasis in fungi remain elusive. In this study, we demonstrate that CcAbl1 is indispensable for the maintenance of glucose metabolism, redox homeostasis and pathogenicity in Cytospora chrysosperma. Loss of CcAbl1 severely compromises glucose utilization, disrupts carbohydrate metabolic pathways, markedly reduces intracellular NADPH levels and virulence. Furthermore, we provided evidence how CcAbl1 is involved in glucose utilization, NADPH balance, glutathione biosynthesis, and oxidative stress tolerance. These results demonstrate that CcAbl1 links virulence to NADPH and glutathione to maintain redox homeostasis in C. chrysosperma.

Indexed as

Carbohydrate metabolismCytospora chrysospermaNADPH-glutathione homeostasisOxidative stress tolerancePathogenicityRedox balance

Identifiers

PMID42032163

DOI10.1007/s44154-026-00302-8

PMCPMC13109457

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.