Evidence map›Paper›PMID 42032154›Full record

ArticlePsychopharmacology2026

17β-Estradiol alleviates cognitive deficits by modulating fear memory reconsolidation in a PTSD rat model.

Han Wang, Han Lin, Zilong Zhong, Baoying Jiang, Siyi Li, Jiahao Tang, Xiaoping Zhou, Guohui Zhu, Yang Liu, Wenhao Han and 2 more

Abstract read
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In one paragraph

Article in Psychopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Han WangSchool of Mental Health, Jining Medical University, 133# Hehua Road, Taibai Lake New District, Jining, Shandong, 272067, P. R. China.
Han LinSchool of Psychology, Shandong Second Medical University, 7166# Baotong West Street, Weifang, Shandong, 261053, P. R. China.
Zilong ZhongSchool of Psychology, Shandong Second Medical University, 7166# Baotong West Street, Weifang, Shandong, 261053, P. R. China.
Baoying JiangSchool of Psychology, Shandong Second Medical University, 7166# Baotong West Street, Weifang, Shandong, 261053, P. R. China.
Siyi LiDepartment of Clinical Medicine, Shandong Second Medical University, 7166# Baotong West Street, Weifang, Shandong, 261053, P. R. China.
Jiahao TangThe First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, 150086, P. R. China.
Xiaoping ZhouNetwork Information Center, Shandong Second Medical University, 7166# Baotong West Street, Weifang, Shandong, 261053, P. R. China.
Guohui ZhuWeifang Mental Health Center, 8899# Wei'an Road, High-Tech Zone, Weifang, Shandong, 261000, P. R. China.
Yang LiuWeifang Mental Health Center, 8899# Wei'an Road, High-Tech Zone, Weifang, Shandong, 261000, P. R. China.
Wenhao HanSchool of Psychology, Shandong Second Medical University, 7166# Baotong West Street, Weifang, Shandong, 261053, P. R. China.
Jinhua DouMental Health Education Centre for University Students, Shandong Second Medical University, Weifang, Shandong, China. jinhuadou@sdsmu.edu.cn.
Lin SunSchool of Psychology, Shandong Second Medical University, 7166# Baotong West Street, Weifang, Shandong, 261053, P. R. China. linsun2013@sdsmu.edu.cn.

Funding

Education and Teaching Reform and Research Project of Shandong Second Medical University 2025YB012Shandong Provincial Medical and Health Science and Technology Project 202423010194the National Natural Science Foundation of China 82101588Weifang City Science and Technology Development Plan Project 2025YX067Weifang Medical University Scientific Research Innovation Project 2023BSQD040
6 · The paper itself

Abstract

rationaleImpaired fear memory extinction is a core symptom of post-traumatic stress disorder (PTSD). Alleviating pathological fear memory is crucial for treating PTSD and related fear disorders.

objectives17β-estradiol (17β-E2) critically regulates hippocampal learning and memory. This study explored effects of gonadal and hippocampal 17β-E2 on cognitive function during fear memory reconsolidation in a rat PTSD model.

methodsIn female rats, ovariectomy with intraperitoneal 17β-E2 injection manipulated gonadal hormone levels, while intracerebral letrozole regulated hippocampal 17β-E2 synthesis.

resultsSPS-CFC model rats showed enhanced fear responses and anxiety-depression-like behaviors during fear memory reconsolidation. Elevated 17β-E2 ameliorated these PTSD-like phenotypes. Hippocampal mRNA and protein levels of PSD‑95, ERK1/2, p‑ERK1/2, and BDNF were upregulated, and synaptic structure improved.

conclusionsThese findings demonstrate that both gonadal-derived and hippocampus-derived 17β-E2 relieve cognitive deficits and emotional disorders during fear memory reconsolidation in PTSD model rats, providing a potential target for PTSD intervention.

Indexed as

17β-EstradiolFear memoryLetrozoleMemory reconsolidationPost-traumatic stress disorder

Identifiers

PMID42032154

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.