Evidence map›Paper›PMID 42032121›Full record

ArticleScientific reports2026

Peptide-enriched hydrogel formulation for sensitive and damaged skin: from design to application testing.

Deptuła Milena, Zawrzykraj Małgorzata, Sawicka Justyna, Dzierżyńska Maria, Skoniecka Aneta, Czerwiec Katarzyna, Kondej Karolina, Zieliński Jacek, Janus Łukasz, Rodziewicz-Motowidło Sylwia and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Deptuła MilenaLaboratory of Tissue Engineering and Regenerative Medicine, Division of Embryology, Medical University of Gdańsk, Gdańsk, Poland. milena.deptula@gumed.edu.pl.
Zawrzykraj MałgorzataDivision of Clinical Anatomy, Medical University of Gdańsk, Gdańsk, Poland.
Sawicka JustynaDepartment of Biomedical Chemistry, Faculty of Chemistry, University of Gdańsk, Gdańsk, Poland.
Dzierżyńska MariaDepartment of Biomedical Chemistry, Faculty of Chemistry, University of Gdańsk, Gdańsk, Poland.
Skoniecka AnetaLaboratory of Tissue Engineering and Regenerative Medicine, Division of Embryology, Medical University of Gdańsk, Gdańsk, Poland.
Czerwiec KatarzynaDivision of Clinical Anatomy, Medical University of Gdańsk, Gdańsk, Poland.
Kondej KarolinaDepartment of Plastic Surgery, Medical University of Gdańsk, Gdańsk, Poland.
Zieliński JacekDepartment of Surgical Oncology, Transplant Surgery and General Surgery, Medical University of Gdańsk, Gdańsk, Poland.
Janus ŁukaszBioGel Sp. Z O.O., Szybowcowa 8a, 80-298, Gdańsk, Poland.
Rodziewicz-Motowidło SylwiaDepartment of Biomedical Chemistry, Faculty of Chemistry, University of Gdańsk, Gdańsk, Poland.
Pikuła MichałLaboratory of Tissue Engineering and Regenerative Medicine, Division of Embryology, Medical University of Gdańsk, Gdańsk, Poland.

Funding

Incubator grant program, Research University, Medical University of Gdańsk 61-00206
6 · The paper itself

Abstract

Various factors such as infections, wounds, and comorbidities can disrupt the skin's physiological function. Moreover, skin lesions can result from radiation therapy. We aimed to create a new cosmetic formulation with pro-regenerative properties that is specifically designed for patients with sustained skin damage, such as those who have undergone radiation therapy. In the first stage, NE1 and IM2 peptides were synthesized, and hydrogels were prepared. IM2 is a derivative of the IM peptide, while NE1 contains the bioactive GHK sequence. In the next stage physicochemical analyses were conducted, including the evaluation of peptide stability and the developed composition's microbial purity and packaging compatibility. In addition, in vitro safety and activity assessments were implemented on human skin cells. In the final step, dermatological tests were conducted on the participants. The results indicate that the cosmetic composition is stable, possesses preservative properties, and is safe in both in vitro and in vivo studies. Peptide release studies show that within the first hours, approximately 75-80% of each peptide is released, ensuring a rapid onset of action. Analysis of cell migration indicate that both p407 and the designed composition stimulate migration of HaCaT keratinocytes in vitro. Dermatological tests did not show any irritant and sensitizing properties. Application analyses revealed that the designed composition effectively moisturizes and takes care of sensitive skin, alleviates redness and the effects of rough skin, eliminates the sensation of itching and the effects of skin tension, and soothes irritation. This formulation can be used for the daily care of sensitive, allergic, or irritated skin.

Indexed as

HydrogelsPeptidesSkinAnimalsCell MovementCosmeticsFemaleHaCaT CellsHumansKeratinocytesCosmeticsHydrogelsPeptides

Identifiers

PMID42032121
PMCPMC13279771

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.