Evidence map›Paper›PMID 42032097›Full record

ArticleNature chemical biology2026

Condensation-independent intramodular translocation mechanism of the trans-AT polyketide synthase assembly line.

Zhicheng Guo, Shijuan Wu, Xiaohua Wang, Gen Lu, Minghe Luo, Yulu Dong, Guo Sun, Zixin Deng, Guifa Zhai, Yuhui Sun

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Article in Nature chemical biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Zhicheng Guo *Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Ministry of Education) and School of Pharmaceutical Sciences, Wuhan University, Wuhan, People's Republic of China.
Shijuan Wu *Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Ministry of Education) and School of Pharmaceutical Sciences, Wuhan University, Wuhan, People's Republic of China.
Xiaohua WangCollege of Life Sciences, Wuchang University of Technology, Wuhan, People's Republic of China.ORCID http://orcid.org/0000-0002-6867-1893
Gen LuSchool of Pharmacy, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
Minghe LuoKey Laboratory of Combinatorial Biosynthesis and Drug Discovery (Ministry of Education) and School of Pharmaceutical Sciences, Wuhan University, Wuhan, People's Republic of China.
Yulu DongKey Laboratory of Combinatorial Biosynthesis and Drug Discovery (Ministry of Education) and School of Pharmaceutical Sciences, Wuhan University, Wuhan, People's Republic of China.
Guo SunKey Laboratory of Combinatorial Biosynthesis and Drug Discovery (Ministry of Education) and School of Pharmaceutical Sciences, Wuhan University, Wuhan, People's Republic of China.ORCID http://orcid.org/0000-0001-9680-0130
Zixin DengKey Laboratory of Combinatorial Biosynthesis and Drug Discovery (Ministry of Education) and School of Pharmaceutical Sciences, Wuhan University, Wuhan, People's Republic of China.
Guifa ZhaiSchool of Pharmacy, Huazhong University of Science and Technology, Wuhan, People's Republic of China. gfzhai@hust.edu.cn.ORCID http://orcid.org/0000-0001-9659-8323
Yuhui SunKey Laboratory of Combinatorial Biosynthesis and Drug Discovery (Ministry of Education) and School of Pharmaceutical Sciences, Wuhan University, Wuhan, People's Republic of China. yhsun@whu.edu.cn.ORCID http://orcid.org/0000-0001-5720-9620

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Decarboxylative condensation drives chain elongation and translocation of polyketides and fatty acids. However, the mechanism by which nonelongating modules in trans-acyltransferase polyketide synthases (trans-AT PKSs) enable intramodular polyketide chain translocation without decarboxylation remains poorly understood. Here we elucidate a condensation-independent intramodular translocation mechanism in which KS

Indexed as

PolyketidesPolyketide SynthasesAcyl Carrier ProteinCatalytic DomainModels, MolecularMutagenesis, Site-DirectedAcyl Carrier ProteinPolyketidesPolyketide Synthases

Identifiers

PMID42032097

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.