Evidence map›Paper›PMID 42032067›Full record

ArticleNature methods2026

Systematically decoding pathological morphologies and molecular profiles with unified multimodal embedding.

Peng Zhang, Chaofei Gao, Kui Hua, Zhuoyu Zhang, Shao Li

Abstract read
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In one paragraph

Article in Nature methods, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Peng Zhang *Institute of TCM-X/MOE Key Laboratory of Bioinformatics, Bioinformatics Division, BNRist/Department of Automation, Tsinghua University, Beijing, China.ORCID http://orcid.org/0000-0002-5858-207X
Chaofei Gao *Institute of TCM-X/MOE Key Laboratory of Bioinformatics, Bioinformatics Division, BNRist/Department of Automation, Tsinghua University, Beijing, China.
Kui HuaCancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0003-2228-7025
Zhuoyu ZhangInstitute of TCM-X/MOE Key Laboratory of Bioinformatics, Bioinformatics Division, BNRist/Department of Automation, Tsinghua University, Beijing, China.
Shao LiInstitute of TCM-X/MOE Key Laboratory of Bioinformatics, Bioinformatics Division, BNRist/Department of Automation, Tsinghua University, Beijing, China. shaoli@mail.tsinghua.edu.cn.ORCID http://orcid.org/0000-0002-8709-9167

Funding

National Natural Science Foundation of China (National Science Foundation of China) 82305047National Natural Science Foundation of China (National Science Foundation of China) T2341008
6 · The paper itself

Abstract

Systematic cross-modality inference and integration of pathological morphologies and multilayer molecular profiles have advanced disease biology; however, methodological challenges remain in multimodal learning. Here, we present Multi-Embed, a unified and interpretable framework for multimodal learning between multilevel morphologies and multilayer molecular profiles. Multi-Embed achieves superior performance in morphology-molecule inference and integration, fine-grained tissue architecture identification and spatiotemporal trajectory modeling across diverse benchmark tasks, underscoring its utility for enhancing our understanding of disease pathogenesis.

Indexed as

DiseaseMachine LearningAlgorithmsHumans

Identifiers

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.