Reviewnpj biomedical innovations2026
Rejuvenating the damaged and aged heart: lessons from development.
Review in npj biomedical innovations, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Mammals have evolutionarily sacrificed their cardiac regenerative capacity in order to maintain high-output contractile function. This developmental trade-off involves integrated metabolic and epigenetic regulation, as well as microenvironmental maturation, all of which contribute to the withdrawal of cardiomyocytes from the cell-cycle. Reactivating juvenile regulatory networks-through the induction of transcription factors, metabolic reprogramming, and modulation of the cellular niche-may offer a strategy to restore proliferative potential in adult cardiomyocytes. Notably, cardiac aging appears to recapitulate the disruption of these regulatory mechanisms. Therefore, we propose that reprogramming strategies capable of reversing the developmental barriers to regeneration may represent a promising approach to counteract cardiac senescence.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.