ArticleScientific reports2026
Comparative metabolic profiling of pediatric cerebrospinal fluid reveals disease-specific biomarkers in HIV and TB meningitis.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
HIV enters the central nervous system (CNS) early, disrupting neurometabolism and inducing chronic neuroinflammation that results in the development of neurocognitive symptoms and neurodevelopmental delay in children infected with HIV. In children, neurocognitive presentation is often more severe than in adults, due to early and prolonged exposure to the virus. Tuberculous meningitis (TBM), another major pediatric CNS infection and often an opportunistic co-infection in HIV, carries high morbidity and mortality but remains difficult to diagnose with existing tests. Metabolomics provides a promising complementary diagnostic approach. We used
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