ArticleScientific reports2026
Exploring insecticidal activity and SAR study of newly synthesized Benzo[h]quinoline-based heterocycles against Aphis craccivora Koch. and Culex pipiens L. Larvae.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The key material, 2-chlorobenzo[h]quinoline-3-carbaldehyde condensed with various active-methylene reagents to produce some benzo[h]quinoline-based heterocycles like pyrazolone, imidazolone, thiazolidine, pyrimidinone, and indolinone candidates. The insecticidal activities of synthesized substrates were evaluated against cowpea aphid, Aphis craccivora, adults and common house mosquito, Culex pipiens larvae. The results of toxicological bioassays demonstrated that compounds 9 and 11, containing 2-thioxoimidazolidine and 2-thioxothiazolidine core, exhibited high insecticidal activity against A. craccivora adults with LC50s of 3.54 and 3.87 µg/mL, and against C. pipiens larvae with LC50s of 1.61 and 1.83 µg/mL, respectively. Schiff base 7 and arylidene 5 (bearing pyrazolone scaffolds) achieved good potencies with low LC50 values of 4.40 and 5.25 µg/mL for A. craccivora adults, and 2.16 and 2.49 µg/mL for C. pipiens larvae, respectively. On the other hand, the bulky pyrimidinetrione 16 and indolone 18 showed low toxicities. Overall, the tested substrates were more effective against C. pipiens larvae than A. craccivora adults. The current study highlighted the effect of the inserted function groups on 2-chlorobenzo[h]quinoline core on the compounds’ activity through the structure-activity relationship (SAR) study. This study presents promising results for the development of novel and effective insecticides to be integrated into pest control programs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.