ArticleScientific reports2026
Prostaglandin E-major urinary metabolite as a potential biomarker of muscle inflammation following physical exercise, considering gender differences.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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5 authors.
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Abstract
Prostaglandin E-major urinary metabolite (PGE-MUM) may be a useful biomarker for assessing muscle inflammation caused by physical exercise. To explore this, both male and female volunteer university students (n = 18) performed gradual loading treadmill tests. Peripheral blood and urine samples were obtained before (T1) and immediately after physical exercise (T2), and 2 h later (T3) for measurement of PGE-MUM. PGE-MUM∙Cr (corrected by urinary creatinine) showed a significant stepwise increase from T1 to T3 in females (p = 0.0171) and the same tendency without significance was observed in males (p = 0.1533). Serum myoglobin showed the same trend, increasing from T1 to T3 in both males and females (p = 0.1690, 0.0443 respectively); Of note, females had a significant correlation between myoglobin and PGE-MUM∙Cr, (p = 0.0456), suggesting the involvement of muscle damage, but not between PGE-MUM∙Cr and peripheral leukocytosis after physical exercise. PGE-MUM∙Cr had no independent association with serum myoglobin after accounting for total muscle weight and maximal oxygen uptake/BW(VO
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