Evidence map›Paper›PMID 42031749›Full record

ArticleNature communications2026

Chromatin accessibility landscape and its association with heterosis in maize hybrids.

Yumin Huang, Kande Lin, Wei Huang, Hainan Zhao, Fengkun Sun, Jingyan Liu, Yilong Gong, Ruilin Xia, Xiaoming Zhao, Jiming Jiang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yumin Huang *Fujian Provincial Key Laboratory of Haixia Applied Plant Systems Biology, Haixia Institute of Science and Technology, Fujian Agriculture and Forestry University, Fuzhou, China.ORCID http://orcid.org/0000-0002-3595-3093
Kande Lin *State Key Laboratory for Crop Genetics and Germplasm Enhancement and Utilization, CIC-MCP, Nanjing Agricultural University, Nanjing, China.
Wei HuangState Key Laboratory of Maize Bio-breeding, Frontiers Science Center for Molecular Design Breeding, National Maize Improvement Center, School of Interdisciplinary Life Sciences, China Agricultural University, Beijing, China.ORCID http://orcid.org/0000-0002-6943-5892
Hainan ZhaoState Key Laboratory of Maize Bio-breeding, Frontiers Science Center for Molecular Design Breeding, National Maize Improvement Center, School of Interdisciplinary Life Sciences, China Agricultural University, Beijing, China.
Fengkun SunTianjin Key Laboratory of Intelligent Breeding of Major Crops, Fresh Corn Research Center of BTH, College of Agronomy & Resources and Environment, Tianjin Agricultural University, Tianjin, China.
Jingyan LiuTianjin Key Laboratory of Intelligent Breeding of Major Crops, Fresh Corn Research Center of BTH, College of Agronomy & Resources and Environment, Tianjin Agricultural University, Tianjin, China.
Yilong GongState Key Laboratory of Maize Bio-breeding, Frontiers Science Center for Molecular Design Breeding, National Maize Improvement Center, School of Interdisciplinary Life Sciences, China Agricultural University, Beijing, China.
Ruilin XiaState Key Laboratory of Maize Bio-breeding, Frontiers Science Center for Molecular Design Breeding, National Maize Improvement Center, School of Interdisciplinary Life Sciences, China Agricultural University, Beijing, China.
Xiaoming ZhaoCenter for Crop Functional Genomics and Molecular Breeding, China Agricultural University, Beijing, China.
Jiming JiangDepartment of Plant Biology, Department of Horticulture, Michigan State University, East Lansing, MI, USA.ORCID http://orcid.org/0000-0002-6435-6140
Wenli ZhangState Key Laboratory for Crop Genetics and Germplasm Enhancement and Utilization, CIC-MCP, Nanjing Agricultural University, Nanjing, China. wzhang25@njau.edu.cn.ORCID http://orcid.org/0000-0003-0710-1966
Weiwei JinState Key Laboratory of Maize Bio-breeding, Frontiers Science Center for Molecular Design Breeding, National Maize Improvement Center, School of Interdisciplinary Life Sciences, China Agricultural University, Beijing, China. weiweijin@cau.edu.cn.
Zhaobin DongState Key Laboratory of Maize Bio-breeding, Frontiers Science Center for Molecular Design Breeding, National Maize Improvement Center, School of Interdisciplinary Life Sciences, China Agricultural University, Beijing, China. zbdong@cau.edu.cn.ORCID http://orcid.org/0000-0002-1275-581X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Accessible chromatin regions (ACRs) encompass diverse cis-regulatory elements (CREs) crucial for gene regulation, but their variations from parents to hybrids and their contribution to heterosis remain poorly understood. Here, using MNase hypersensitivity sequencing (MH-seq) across the maize B73-Mo17 pan-genome, we analyze chromatin accessibility in inbreds and their hybrids. Approximately 81% of ACRs are syntenic in parents, while ~20% show parent-specific accessibility driven by motif divergence. Chromatin accessibility is more stably inherited than transcriptomic profiles, yet ~3.5% of ACRs exhibit non-additive inheritance in hybrid. Among these, transgressively up-regulated ACRs are evolutionarily constrained, enhanced for chromatin modifications and interactions, and localized within enhancers and CRE-clusters serving as regulatory hubs, regulating complex traits including photoperiod and metabolite levels. Overexpression of a candidate rhamnosyl transferase gene under hybrid chromatin context increases plant height, suggesting a potential contribution to heterosis. Our study provides an insightful perspective on the role of chromatin accessibility in driving heterosis.

Indexed as

ChromatinHybrid VigorZea maysGene Expression Regulation, PlantGenome, PlantHybridization, GeneticChromatin

Identifiers

PMID42031749
PMCPMC13316064

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.