Evidence map›Paper›PMID 42031737›Full record

ArticleNature communications2026

2'-O-methylation-dependent installation of N

Nicole Kleiber, Jonny Petrosyan, Maria Greve, Chairini C Thomé, Olexandr Dybkov, Laurianne L E Tay, Luisa M Welp, Philipp Hackert, David Touboul, Holger Stark and 6 more

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Nicole KleiberDepartment of Molecular Biology, University Medical Center Göttingen, Justus-von-Liebig-Weg 11, Göttingen, Germany.ORCID 0000-0003-0844-7547
Jonny PetrosyanDepartment of Molecular Biology, University Medical Center Göttingen, Justus-von-Liebig-Weg 11, Göttingen, Germany.
Maria GreveInstitute of Organic Chemistry, Universität Würzburg, Am Hubland, Würzburg, Germany.
Chairini C ThoméDepartment of Molecular Biology, University Medical Center Göttingen, Justus-von-Liebig-Weg 11, Göttingen, Germany.
Olexandr DybkovMax Planck Institute for Multidisciplinary Sciences, Research Group 'Bioanalytical Mass Spectrometry', Am Fassberg 11, Göttingen, Germany.
Laurianne L E TayLaboratoire de Biologie Structurale de la Cellule (BIOC), CNRS, Ecole polytechnique, Institut Polytechnique de Paris, Palaiseau, France.ORCID 0009-0006-7666-0031
Luisa M WelpMax Planck Institute for Multidisciplinary Sciences, Research Group 'Bioanalytical Mass Spectrometry', Am Fassberg 11, Göttingen, Germany.
Philipp HackertDepartment of Molecular Biology, University Medical Center Göttingen, Justus-von-Liebig-Weg 11, Göttingen, Germany.
David TouboulLaboratoire de Chimie Moleculaire (LCM), CNRS, Ecole polytechnique, Institut Polytechnique de Paris, Palaiseau, France.ORCID 0000-0003-2751-774X
Holger StarkMax Planck Institute for Multidisciplinary Sciences, Research Group 'Structural Dynamics', Am Fassberg 11, Göttingen, Germany.
Markus T BohnsackDepartment of Molecular Biology, University Medical Center Göttingen, Justus-von-Liebig-Weg 11, Göttingen, Germany.
Henning UrlaubMax Planck Institute for Multidisciplinary Sciences, Research Group 'Bioanalytical Mass Spectrometry', Am Fassberg 11, Göttingen, Germany.ORCID 0000-0003-1837-5233
Lydia HerzelInstitute of Chemistry and Biochemistry, Freie Universität Berlin, Takustraße 6, Berlin, Germany.ORCID 0000-0001-8965-290X
Marc GrailleLaboratoire de Biologie Structurale de la Cellule (BIOC), CNRS, Ecole polytechnique, Institut Polytechnique de Paris, Palaiseau, France.ORCID 0000-0002-7853-5852
Claudia HöbartnerInstitute of Organic Chemistry, Universität Würzburg, Am Hubland, Würzburg, Germany.ORCID 0000-0002-4548-2299
Katherine E BohnsackDepartment of Molecular Biology, University Medical Center Göttingen, Justus-von-Liebig-Weg 11, Göttingen, Germany. katherine.bohnsack@med.uni-goettingen.de.ORCID 0000-0001-6035-4255

Funding

Deutsche Forschungsgemeinschaft (German Research Foundation) BO5699/1-1Deutsche Forschungsgemeinschaft (German Research Foundation) SFB1565 (project number 469281184)
6 · The paper itself

Abstract

The internal stem loop (ISL) of the human U6 snRNA, which catalyzes pre-mRNA splicing, contains LARP7-dependent, snoRNA-guided 2'-O-methylations and an N

Indexed as

GuanosineRNA, Small NuclearSpliceosomesAlternative SplicingHeLa CellsHumansMethylationMethyltransferasesRNA MethylationRNA PrecursorsRNA SplicingGuanosineMethyltransferasesRNA PrecursorsRNA, Small NuclearU6 small nuclear RNA

Identifiers

PMID42031737
PMCPMC13109388

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.