Evidence map›Paper›PMID 42031702›Full record

ArticleTranslational psychiatry2026

Delivery of HSP70 mRNA via exosomes ameliorates sleep deprivation-induced cognitive impairments in mice.

Zhenming Kang, Guoshao Zhu, Changsheng Su, Xianmei Zhong, Jianchuan Lin, Yiqin Lin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zhenming Kang *Department of Anesthesiology, Quanzhou First Hospital Affiliated to Fujian Medical University, Quanzhou, 362000, Fujian, China. kangzhenming@fjmu.edu.cn.ORCID http://orcid.org/0009-0001-9714-2552
Guoshao Zhu *Department of Anesthesiology, Quanzhou First Hospital Affiliated to Fujian Medical University, Quanzhou, 362000, Fujian, China.
Changsheng Su *Department of Anesthesiology, Quanzhou First Hospital Affiliated to Fujian Medical University, Quanzhou, 362000, Fujian, China.
Xianmei ZhongDepartment of Anesthesiology, Quanzhou First Hospital Affiliated to Fujian Medical University, Quanzhou, 362000, Fujian, China.
Jianchuan LinDepartment of Anesthesiology, Quanzhou First Hospital Affiliated to Fujian Medical University, Quanzhou, 362000, Fujian, China.
Yiqin LinDepartment of Anesthesiology, Quanzhou First Hospital Affiliated to Fujian Medical University, Quanzhou, 362000, Fujian, China. linyiqinmed@sina.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic sleep deprivation impairs cognition and triggers neuroinflammation, but effective molecular therapies are lacking. Heat shock protein 70 (HSP70) offers neuroprotection, though its delivery across the blood-brain barrier remains a challenge. This study investigates exosomes as a vehicle to enhance brain delivery of HSP70 for treating chronic sleep deprivation. We engineered HEK293T cells to stably express HSP70 mRNA and the brain-targeting RVG-Lamp2b fusion protein, generating HSP70@Exo

Indexed as

Cognitive DysfunctionExosomesHSP70 Heat-Shock ProteinsRNA, MessengerSleep DeprivationAnimalsBrain-Derived Neurotrophic FactorDisease Models, AnimalHEK293 CellsHippocampusHumansMaleMiceMice, Inbred C57BLNeural Stem CellsBrain-Derived Neurotrophic FactorHSP70 Heat-Shock ProteinsRNA, Messenger

Identifiers

PMID42031702
PMCPMC13243628

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.