Evidence map›Paper›PMID 42031673›Full record

ArticleLife science alliance2026

Convergent transcriptomic signature in iPSC-dopaminergic neurons of hereditary Parkinson's disease.

Irina V Kopylova, Artem B Ivanov, Lev R Eidelman, Ekaterina N Zaitseva, Ekaterina D Kulikova, Dmitriy A Grehnyov, Alexandra N Bogomazova, Vladimir A Vigont, Elena V Kaznacheyeva, Maria A Lagarkova and 2 more

Abstract read
In one paragraph

Article in Life science alliance, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Irina V KopylovaLopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Moscow, Russia.ORCID 0009-0002-0258-0291
Artem B IvanovLopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Moscow, Russia.
Lev R EidelmanITMO University, St. Petersburg, Russia.ORCID 0009-0001-9345-3249
Ekaterina N ZaitsevaITMO University, St. Petersburg, Russia.
Ekaterina D KulikovaITMO University, St. Petersburg, Russia.ORCID 0009-0002-3218-1494
Dmitriy A GrehnyovInstitute of Cytology, Russian Academy of Sciences, St. Petersburg, Russia.ORCID 0000-0003-2338-6252
Alexandra N BogomazovaLopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Moscow, Russia.
Vladimir A VigontInstitute of Cytology, Russian Academy of Sciences, St. Petersburg, Russia.
Elena V KaznacheyevaInstitute of Cytology, Russian Academy of Sciences, St. Petersburg, Russia.
Maria A LagarkovaLopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Moscow, Russia.ORCID 0000-0001-9594-1134
Olga S LebedevaLopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Moscow, Russia.ORCID 0000-0003-0767-5265
Evgenii I OlekhnovichLopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Moscow, Russia jeniaole01@gmail.com.ORCID 0000-0003-4899-342X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The clinical and genetic diversity of Parkinson's disease (PD) makes it challenging to identify common mechanisms across different forms. To search for such shared pathways, we performed transcriptomic analysis of iPSC-derived dopaminergic neurons from patients with

Indexed as

Dopaminergic NeuronsInduced Pluripotent Stem CellsParkinson DiseaseTranscriptomeCell DifferentiationGene Expression ProfilingHumansLeucine-Rich Repeat Serine-Threonine Protein Kinase-2MutationUbiquitin-Protein LigasesLeucine-Rich Repeat Serine-Threonine Protein Kinase-2LRRK2 protein, humanparkin proteinUbiquitin-Protein Ligases

Identifiers

PMID42031673
PMCPMC13109591

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.