Evidence map›Paper›PMID 42031436›Full record

ReviewGastroenterology2026

Fundamentals of Neurogastroenterology: Basic Science.

Beverley Greenwood-Van Meerveld, Gary M Mawe, Arthur Beyder, Stuart M Brierley, Gerard Clarke, Brian D Gulbransen, Kara G Margolis

Abstract readReview
In one paragraph

Review in Gastroenterology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Beverley Greenwood-Van MeerveldDepartment of Biochemistry and Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma. Electronic address: Beverley-Greenwood@ouhsc.edu.
Gary M MaweDepartment of Neurological Sciences, Larner College of Medicine, University of Vermont, Burlington, Vermont.
Arthur BeyderEnteric NeuroScience Program, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.
Stuart M BrierleySouth Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.
Gerard ClarkeDepartment of Psychiatry and Neurobehavioural Science, University College Cork, Cork, Ireland.
Brian D GulbransenDepartment of Physiology, Michigan State University, East Lansing, Michigan.
Kara G MargolisPain Research Center and Department of Molecular Pathobiology, New York University, College of Dentistry, New York, New York.

Funding

Role of enteric glia in the death of neurons during gut inflammationR01DK103723 · NIDDK · MICHIGAN STATE UNIVERSITY · PI BRIAN D. GULBRANSEN · 2015 to 2026
$4.7M
Enteric glia and visceral painR01DK120862 · NIDDK · MICHIGAN STATE UNIVERSITY · PI BRIAN D. GULBRANSEN · 2019 to 2026
$3.0M
NIDDK NIH HHS R01 DK103723NIDDK NIH HHS R01 DK120862
6 · The paper itself

Abstract

This review highlights major advances in neurogastroenterology since Rome IV, offering a condensed summary of a comprehensive document to appear in the forthcoming Rome V book. Prepared by an international team of experts, it emphasizes pivotal studies that have deepened understanding of the physiological and pathophysiological mechanisms underlying disorders of gut-brain interaction (DGBI). These disorders are inherently complex and multifactorial, shaped by interactions among neuronal, epithelial, immune, smooth muscle, interstitial, and microbial populations. The review outlines cutting-edge technologies advancing the field and explores key themes, including brain-gut interactions, neurobiology, and neuroplasticity of the enteric nervous system, neuroimmune function, microbiome influences, and abnormalities of the gut-brain axis in DGBI. Risk factors for DGBI are considered, with serotonergic signaling presented as a conceptual framework for linking symptomatology and pathophysiology. Finally, we discuss how these scientific advances can translate into novel therapeutic strategies to improve patient care.

Indexed as

BrainBrain-Gut AxisEnteric Nervous SystemGastroenterologyGastrointestinal DiseasesGastrointestinal TractAnimalsGastrointestinal MicrobiomeHumansNeuronal PlasticitySignal TransductionCentral Nervous SystemEnteric Nervous SystemNeuroplasticitySerotonergic Signaling

Identifiers

PMID42031436
PMCPMC13549701

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.