ArticleThe Journal of nutrition2026
A Nutrient-Dense Diet with Optimal Protein Level Restores Goblet Cells and Alleviates Microbial Dysbiosis in a Mouse Model of Colitis.
Article in The Journal of nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundChronic intestinal inflammation is a key driver of colitis-associated colorectal cancer. A mouse model with intestinal epithelial cell-specific knockout (KO) of heterogeneous nuclear ribonucleoprotein I (hnRNPI KO) spontaneously develops colitis and reduces goblet cell numbers, mimicking the pathological symptoms observed in humans with chronic intestinal inflammation, making the hnRNPI KO mouse an invaluable model of gut inflammation. Although higher dietary protein has been associated with lower inflammation and restoration of immune adaptation, the mechanisms remain unclear.
objectivesThis study aimed to investigate the effects of optimized dietary protein on colonic goblet cell functions and on correcting gut dysbiosis in the hnRNPI KO mouse model.
methodsMale wild type (WT) and hnRNPI KO mice were fed either a control protein diet (CON; 14.41% kcal protein) or a nutrient-dense modified diet (MOD; 28.83% kcal protein) for 22 wk. Body weight, food intake, and colon histology were assessed. Goblet cells and mucin content were quantified using Alcian Blue/periodic acid-Schiff staining. CD4
resultsFeeding the MOD restored goblet cell numbers and mucin content in KO mice (P < 0.05). MOD-fed KO mice had significantly lower IL-17
conclusionsAn optimized dietary protein restores colon goblet cells, modulates immune responses, and alleviates gut microbial dysbiosis. Our results highlight the benefits of optimized dietary protein in ameliorating intestinal inflammation and potentially enhancing gut health.
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