Evidence map›Paper›PMID 42030954›Full record

ArticleImmunity2026

Homeostatic mature dendritic cells instruct fibroblast specialization via Notch2 signaling to establish T cell niches.

Nagham Alouche, Hélène Cannelle, Stéphanie Favre, Marija Jokić, José A Villegas, Sandra Maréchal, Clint De Nolf, Maeva Delacrétaz, Alexandros Sifis, Chloé Chapuis and 13 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Dendritic cell PD-L2 restrains intratumoral CD8bioRxiv : the preprint server for biology · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Nagham AloucheDepartment of Immunobiology, University of Lausanne (UNIL), 1066 Epalinges, Switzerland. Electronic address: nagham.alouche@unil.ch.
Hélène CannelleDepartment of Immunobiology, University of Lausanne (UNIL), 1066 Epalinges, Switzerland.
Stéphanie FavreDepartment of Immunobiology, University of Lausanne (UNIL), 1066 Epalinges, Switzerland.
Marija JokićDepartment of Immunobiology, University of Lausanne (UNIL), 1066 Epalinges, Switzerland.
José A VillegasDepartment of Immunobiology, University of Lausanne (UNIL), 1066 Epalinges, Switzerland.
Sandra MaréchalLaboratory for ER Stress and Inflammation, VIB Center for Inflammation Research, Ghent, Belgium; Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium.
Clint De NolfLaboratory for ER Stress and Inflammation, VIB Center for Inflammation Research, Ghent, Belgium; Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium.
Maeva DelacrétazDepartment of Immunobiology, University of Lausanne (UNIL), 1066 Epalinges, Switzerland.
Alexandros SifisDepartment of Immunobiology, University of Lausanne (UNIL), 1066 Epalinges, Switzerland.
Chloé ChapuisDepartment of Immunobiology, University of Lausanne (UNIL), 1066 Epalinges, Switzerland.
Allison BurnsBioinformatics Competence Center, UNIL, Lausanne, Switzerland; Bioinformatics Competence Center, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
Giovanna AmbrosiniBioinformatics Competence Center, UNIL, Lausanne, Switzerland; Bioinformatics Competence Center, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
Isabelle DupanloupSwiss Institute of Bioinformatics, Lausanne, Switzerland.
Jun AbeDepartment of Oncology, Microbiology and Immunology, University of Fribourg, Fribourg, Switzerland.
Ute KochEPFL, Swiss Institute for Experimental Cancer Research, Lausanne, Switzerland.
Nicolas GuexBioinformatics Competence Center, UNIL, Lausanne, Switzerland; Bioinformatics Competence Center, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
Jens V SteinDepartment of Oncology, Microbiology and Immunology, University of Fribourg, Fribourg, Switzerland.
Ivan MaillardDivision of Hematology-Oncology, University of Pennsylvania, Philadelphia, PA, USA; Division of Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Tom CupedoDepartment of Hematology, Erasmus MC Cancer Institute, Rotterdam, the Netherlands.
Burkhard LudewigInstitute of Immunobiology, Cantonal Hospital, St. Gallen, Switzerland.
Freddy RadtkeEPFL, Swiss Institute for Experimental Cancer Research, Lausanne, Switzerland.
Sophie JanssensLaboratory for ER Stress and Inflammation, VIB Center for Inflammation Research, Ghent, Belgium; Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium.
Sanjiv A LutherDepartment of Immunobiology, University of Lausanne (UNIL), 1066 Epalinges, Switzerland. Electronic address: sanjiv.luther@unil.ch.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
Notch Signaling in AlloimmunityR01AI091627 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI PEAR, WARREN S · 2011 to 2025
$6.0M
Notch ligands as oncogenic drivers and therapeutic targets in T-cell lymphomasR01CA278976 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Ivan Maillard, Ryan A Wilcox · 2024 to 2026
$1.9M
NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA278976NIAID NIH HHS R01 AI091627
6 · The paper itself

Abstract

Compartmentalization of secondary lymphoid organs is orchestrated by specialized fibroblastic reticular cells (FRCs), which guide immune cell migration, interaction, and function. Here, we investigated the pathways driving FRC differentiation into functionally distinct subsets. A Notch signaling signature distinguished lymph node (LN) FRCs, and deletion of Notch1 and Notch2 in FRCs restricted functional specialization, particularly for T-zone FRCs (T-zone reticular cells [TRCs]). Dendritic cell (DC)-specific deletion of the Notch ligand Jagged-1 prevented Ccl19

Indexed as

CD8-Positive T-LymphocytesDendritic CellsFibroblastsReceptor, Notch2AnimalsCell DifferentiationChemokine CCL19HomeostasisHumansJagged-1 ProteinLymph NodesMiceMice, Inbred C57BLMice, KnockoutReceptor, Notch1Receptors, CCR7Ccl19 protein, mouseCcr7 protein, mouseChemokine CCL19Jag1 protein, mouseJagged-1 ProteinNotch2 protein, mouseReceptor, Notch1Receptor, Notch2Receptors, CCR7Ccl19Ccr7CD8+ T memory precursor cellscompartmentalizationdendritic cellsfibroblastic reticular cellshomeostasislymph nodeNotch signalingsecondary lymphoid organsT cell zone

Identifiers

PMID42030954
PMCPMC13182424

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.