ArticleVeterinary medicine and science2026
Pharmacokinetics of Flunixin and Tolfenamic Acid in Experimental Endotoxemic Awassi Sheep.
Article in Veterinary medicine and science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Migraine is Associated With Altered Preoperative Endodontic Pain Perception and Mechanical Sensory Function but Not Short-Term Postoperative Pain: A Prospective Clinical Study.Journal of oral rehabilitation · 2026Observational
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Authors and funding
8 authors.
Funding
Abstract
objectiveThe purpose of this study was to investigate the pharmacokinetic alterations of flunixin and tolfenamic acid in experimental endotoxemic sheep.
methodsThe study was conducted on 12 healthy Awassi sheep. The sheep were divided into two equal groups, tolfenamic acid (n = 6) and flunixin (n = 6), and the study in each group was carried out in two stages. The initial stage involved the intravenous (IV) administration of flunixin and tolfenamic acid to healthy sheep at doses of 2.2 mg/kg and 4 mg/kg, respectively. In the second stage, sheep were administered LPS (E. coli O55:B5, 10 µg/kg) followed by IV administration of tolfenamic acid and flunixin. The analysis of drugs was performed using HPLC-UV, and pharmacokinetic parameters were calculated by non-compartmental analysis.
resultsThe t
conclusionsThe altered pharmacokinetics of flunixin and tolfenamic acid in endotoxemic sheep suggest that dose adjustments and careful therapeutic monitoring are necessary to maintain efficacy and safety.
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