Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
17 authors.
Elza RechtmanDepartment of Environmental Medicine and Climate Science, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-5034-6048
Avraham ReichenbergDepartment of Environmental Medicine and Climate Science, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Azzurra InvernizziDepartment of Environmental Medicine and Climate Science, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0001-7411-8552
Lazar FleysherBioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Vida RebelloDepartment of Environmental Medicine and Climate Science, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Kristie OluyemiDepartment of Environmental Medicine and Climate Science, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Michelle A RodriguezDepartment of Environmental Medicine and Climate Science, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Anna SatherDepartment of Environmental Medicine and Climate Science, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Libni A Torres-OlascoagaCenter for Nutrition and Health Research, National Institute of Public Health, Cuernavaca, Mexico.ORCID 0000-0002-9231-9937
Luis F Bautista-ArredondoCenter for Nutrition and Health Research, National Institute of Public Health, Cuernavaca, Mexico.
Sandra Martínez-MedinaNational Institute of Perinatology, Mexico City, Mexico.ORCID 0000-0002-9829-4881
Rafael Lara-EstradaNational Research Center in Imaging and Medical Instrumentation, Universidad Autónoma Metropolitana, Mexico City, Mexico.ORCID 0000-0001-9299-9090
Chris GenningsDepartment of Environmental Medicine and Climate Science, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-6058-5907
Martha M Téllez-RojoCenter for Nutrition and Health Research, National Institute of Public Health, Cuernavaca, Mexico.ORCID 0000-0003-3322-3334
Robert O WrightDepartment of Environmental Medicine and Climate Science, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0003-1180-6459
Manish AroraDepartment of Environmental Medicine and Climate Science, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-3350-4657
Megan K HortonDepartment of Environmental Medicine and Climate Science, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Funding
Conduits: Mount Sinai Health System Translational Science HubUL1TR004419 · NCATS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Rosalind J Wright · 2022 to 2026
$46.4M
Untargeted Analysis ResourceU2CES026561 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI WRIGHT, ROBERT O · 2015 to 2025
$24.5M
The Mount Sinai Transdisciplinary Center on Early Environmental ExposuresP30ES023515 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Robert O Wright · 2014 to 2026
$21.3M
Untargeted Analysis ResourceU2CES030859 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ARORA, MANISH · 2019 to 2025
$8.2M
Early Warning Systems for Childhood and Adult DisordersR35ES030435 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Manish Arora · 2020 to 2026
$6.7M
Organic-metal mixtures and neurodevelopmentR01ES026033 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Manish Arora, Robert O Wright · 2016 to 2026
$6.1M
Longitudinal study of metal mixtures and the developmental origins of adolescent risk-takingR01ES028927 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Megan K Horton · 2018 to 2026
$5.3M
Air Pollution, Multidimensional Behavior, and Neuroimaging in Children with Neurodevelopmental DisordersR00ES035120 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Elza Rechtman · 2025 to 2026
$498k
Air Pollution, Multidimensional Behavior, and Neuroimaging in Children with Neurodevelopmental DisordersK99ES035120 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI RECHTMAN, ELZA · 2023 to 2024
Exposure to neurotoxic metals early in life can disrupt brain development and increase risk of later mental health problems, but vulnerable periods and underlying mechanisms remain unclear. We examined how early life exposures to mixtures of metals affect children's brain and behavior using naturally shed "baby" teeth as a biomarker of direct exposure. We studied 489 children aged 8 to 14 years and reconstructed weekly concentrations of nine metals from 20 weeks before birth to 40 weeks after birth. We assessed behavior using standardized questionnaires and measured brain structure and function with magnetic resonance imaging. Using lagged weighted quantile sum regression, we identified sensitive developmental windows during which higher exposure to metal mixtures was linked to more behavioral problems, smaller brain volume, reduced brain global efficiency, and weaker white matter integrity. Findings suggest that the developing brain is especially vulnerable to metals in early life, with lasting effects into adolescence.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Fetal and postnatal metal metabolism-related changes in brain function are associated with childhood behavioral deficits. · full record | OpenQuestion