ArticleAmerican journal of physiology. Lung cellular and molecular physiology2026
Global knockout of melanoma differentiation-associated protein 5 protects mice from chronic hypoxia/SU5416-induced pulmonary hypertension.
Dania Abu-Saleh, Ganesh R Koshre, Bryce Piper, Cankun Wang, Cameron Peirce, Benjamin S Johnson, Daniela Farkas, Richard S Nho, Jeffrey C Horowitz, Qin Ma and 3 more
Abstract read
In one paragraphArticle in American journal of physiology. Lung cellular and molecular physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
13 authors.
Dania Abu-SalehDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States.
Ganesh R KoshreDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States.ORCID 0009-0005-8079-5038 Bryce PiperDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States.
Cankun WangDivision of Bioinformatics & Computational Biology, Department of Biomedical Informatics, The Ohio State University, Columbus, Ohio, United States.
Cameron PeirceDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States.
Benjamin S JohnsonDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States.
Daniela FarkasDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States.ORCID 0000-0002-7223-1268 Richard S NhoDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States.ORCID 0000-0002-8023-5680 Jeffrey C HorowitzDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States.ORCID 0000-0002-1505-2837 Qin MaDivision of Bioinformatics & Computational Biology, Department of Biomedical Informatics, The Ohio State University, Columbus, Ohio, United States.ORCID 0000-0002-3264-8392 Rama K MallampalliDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States.ORCID 0000-0002-5782-4495 Elena A GoncharovaDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, University of California Davis, Davis, California, United States.ORCID 0000-0001-7118-6752 Laszlo FarkasDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States.ORCID 0000-0003-3772-470X Funding
Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Tasleem J Padamsee · 1985 to 2026
$132.3MPulmonary Hypertension Breakthrough InitiativeR24HL123767 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI ALDRED, MICHEALA A, ERZURUM, SERPIL C. · 2014 to 2017
$10.1MRegulation and Function of RAB7 in the pulmonary endotheliumR01HL139881 · NHLBI · VIRGINIA COMMONWEALTH UNIVERSITY · PI Laszlo Farkas · 2019 to 2026
$3.8MLDHA-lactate signaling in pulmonary arterial hypertensionR01HL172488 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Elena Goncharova · 2024 to 2026
$2.0MHypoxia-induced aberrant lactate generation and shuttling serves as a direct signal to promote pro-fibrotic fibroblast phenotypesR01HL171164 · NHLBI · OHIO STATE UNIVERSITY · PI Jeffrey C Horowitz, Richard S. Nho · 2025 to 2026
$1.5MStructured Illumination Microscope for high resolution imaging of cells and tissuesS10OD025008 · OD · OHIO STATE UNIVERSITY · PI STOODLEY, PAUL · 2019 to 2019
$593kAmerican Heart Association (AHA) 25TPA1467093Cardiovascular Medical Research and Education Fund (CMREF)HHS | NIH | National Cancer Institute (NCI) P30CA016058HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL139881HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL172488HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R24HL123767NCI NIH HHS P30 CA016058NHLBI NIH HHS R01 HL139881NHLBI NIH HHS R01 HL171164NHLBI NIH HHS R01 HL172488NHLBI NIH HHS R24 HL123767NIH HHS S10 OD025008ODCDC CDC HHS S10 OD025008
6 · The paper itselfAbstract
Pulmonary arterial hypertension (PAH) is a severe disease affecting the pulmonary arteries, causing increased blood pressure due to narrowing of the pulmonary artery lumen. Aberrant proliferation of endothelial cells (ECs) and smooth muscle cells (SMCs), along with a dysregulation of the immune response, contributes to arterial remodeling. We hypothesized that the cytosolic RNA receptor melanoma differentiation-associated protein 5 (MDA5) contributes to PAH by dysregulating pulmonary vascular cell function and immune cell response. In lung tissue from control patients and patients with PAH, MDA5 immunoreactivity was widely distributed throughout the pulmonary artery wall. After exposing whole body
Indexed as
Hypertension, PulmonaryHypoxiaInterferon-Induced Helicase, IFIH1AnimalsEndothelial CellsHumansIndolesMaleMiceMice, Inbred C57BLMice, KnockoutMyocytes, Smooth MusclePulmonary ArteryPyrrolesIFIH1 protein, humanIfih1 protein, mouseIndolesInterferon-Induced Helicase, IFIH1PyrrolesSemaxinibendothelialimmune dysregulationmelanoma differentiation-associated protein 5pulmonary hypertension
Identifiers
PMID42030239
PMCPMC13218392
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