ArticleCell reports2026
PKR condensation at viral replication complexes initiates its activation.
Article in Cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- PKR engages viral RNA and intron-retained host transcripts during poxvirus infection.Cell reports · 2026Article
- MERS-CoV accessory ORF proteins in innate immune evasion: an evidence-graded functional framework.Frontiers in immunology · 2026Review
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- Update of
Authors and funding
6 authors.
Funding
Abstract
Protein kinase R (PKR) is a critical component of mammalian intracellular antiviral immunity. Here, we examine the process of PKR activation in response to Middle East respiratory syndrome coronavirus (MERS-CoV) and Zika virus (ZIKV) using super-resolution confocal microscopy, proximity ligation assay, immunogold transmission electron microscopy, and live-cell imaging. Our data support that PKR activates upon condensation on double-stranded RNA (dsRNA) exposed at membrane-associated viral replication complexes. Subsequently, p-PKR condensates disassociate from dsRNA and dissolve, releasing activated PKR molecules into the cytosol, where they phosphorylate eIF2α to initiate the integrated stress response (ISR). Importantly, the disassociation of p-PKR from dsRNA allows for the exchange of inactive PKR monomers, thus promoting robust PKR activation from limited exposed viral dsRNA substrates. MERS-CoV NS4a prevents PKR activation via competitive condensation on viral dsRNA. These findings establish a comprehensive model for PKR activation in response to positive-strand RNA viruses that replicate within membrane-associated complexes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.