ArticleProceedings of the National Academy of Sciences of the United States of America2026
Monoclonal antibodies against nitrated nerve growth factor reveal an oxidation-dependent pathogenic hallmark in ALS.
Valentina Varela, Santiago Garcimartín, Emiliano Trias, Ari Zeida, Monique Richter, Andrés de León, Ernesto Miquel, Peter H King, Brigitte Vulliez-Le Normand, Mariano Martinez and 4 more
Abstract read
In one paragraphArticle in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
14 authors.
Valentina Varela *Laboratorio de Neurodegeneración, Institut Pasteur de Montevideo, Montevideo 11400, Uruguay.
Santiago Garcimartín *Departamento de Bioquímica, Facultad de Medicina, Universidad de la República, Montevideo 11800, Uruguay.ORCID 0009-0000-6122-3660 Emiliano Trias *Departamento de Neurobiología Celular y Molecular, Instituto de Investigaciones Biológicas Clemente Estable Montevideo, Montevideo 11600, Uruguay.
Ari ZeidaDepartamento de Bioquímica, Facultad de Medicina, Universidad de la República, Montevideo 11800, Uruguay.ORCID 0000-0003-0938-287X Monique RichterLaboratorio de Neurodegeneración, Institut Pasteur de Montevideo, Montevideo 11400, Uruguay.
Andrés de LeónLaboratorio de Neurodegeneración, Institut Pasteur de Montevideo, Montevideo 11400, Uruguay.
Ernesto MiquelDepartamento de Histología y Embriología, Facultad de Medicina, Universidad de la República, Montevideo 11800, Uruguay.
Peter H KingDepartment of Neurology and Killion Center for Neurodegeneration and Experimental Therapeutics, University of Alabama, Birmingham, AL 35294.
Brigitte Vulliez-Le NormandUnité de Microbiologie Structurale, Département de Biologie Structurale et Chimie, Institut Pasteur, CNRS, Université Paris Cité, Paris 75015, France.
Mariano MartinezUnité de Microbiologie Structurale, Département de Biologie Structurale et Chimie, Institut Pasteur, CNRS, Université Paris Cité, Paris 75015, France.ORCID 0000-0003-4460-8045 Pedro M AlzariUnité de Microbiologie Structurale, Département de Biologie Structurale et Chimie, Institut Pasteur, CNRS, Université Paris Cité, Paris 75015, France.ORCID 0000-0002-4233-1903 Silvina BartesaghiDepartamento de Bioquímica, Facultad de Medicina, Universidad de la República, Montevideo 11800, Uruguay.
Rafael RadiDepartamento de Bioquímica, Facultad de Medicina, Universidad de la República, Montevideo 11800, Uruguay.ORCID 0000-0002-1114-1875 Luis BarbeitoLaboratorio de Neurodegeneración, Institut Pasteur de Montevideo, Montevideo 11400, Uruguay.
Funding
UdelaR | Comisión Sectorial de Investigación Científica (CSIC) CSIC I _ 2023UdelaR | Comisión Sectorial de Investigación Científica (CSIC) CSIC I + D _ 2022Universidad de la República Uruguay (UdelaR) EI_2020
6 · The paper itselfAbstract
Nerve growth factor (NGF) is a member of the neurotrophin family, essential for neuronal survival and phenotypic maintenance. However, in vitro, its function can be disrupted by oxidative posttranslational modifications such as tyrosine nitration. Nitrated NGF (NO
Indexed as
Amyotrophic Lateral SclerosisNerve DegenerationNerve Growth FactorAnimalsAntibodies, MonoclonalFemaleHumansMaleMiceMice, Inbred BALB CMotor NeuronsNitro CompoundsOxidation-ReductionPC12 CellsRatsRats, Sprague-DawleyAntibodies, MonoclonalNerve Growth FactorNitro CompoundsALScrystallographymonoclonal antibodiesnerve growth factortyrosine nitration
Identifiers
PMID42030149
PMCPMC13123920
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