ArticleProceedings of the National Academy of Sciences of the United States of America2026
A conserved E3 ubiquitin ligase rewires carotenoid, sterol, and lipid metabolism in
Ruilin Huang, Jiurong Wang, Ruirui Ding, Yu Liu, Juanjuan Su, Zhihang Chen, Yong Fan, Fuli Li, Linqi Wang, Xiao Liu and 1 more
Abstract read
In one paragraphArticle in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
11 authors.
Ruilin HuangShandong Provincial Key Laboratory of Synthetic Biology, Key Laboratory of Photoelectric Conversion and Utilization of Solar Energy, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, China.ORCID 0000-0002-2093-6733 Jiurong WangShandong Provincial Key Laboratory of Synthetic Biology, Key Laboratory of Photoelectric Conversion and Utilization of Solar Energy, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, China.ORCID 0009-0005-5686-1808 Ruirui DingShandong Provincial Key Laboratory of Synthetic Biology, Key Laboratory of Photoelectric Conversion and Utilization of Solar Energy, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, China.
Yu LiuShandong Provincial Key Laboratory of Synthetic Biology, Key Laboratory of Photoelectric Conversion and Utilization of Solar Energy, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, China.ORCID 0000-0001-5172-4306 Juanjuan SuShandong Provincial Key Laboratory of Synthetic Biology, Key Laboratory of Photoelectric Conversion and Utilization of Solar Energy, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, China.
Zhihang ChenShandong Provincial Key Laboratory of Synthetic Biology, Key Laboratory of Photoelectric Conversion and Utilization of Solar Energy, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, China.
Yong FanShandong Provincial Key Laboratory of Synthetic Biology, Key Laboratory of Photoelectric Conversion and Utilization of Solar Energy, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, China.
Fuli LiShandong Provincial Key Laboratory of Synthetic Biology, Key Laboratory of Photoelectric Conversion and Utilization of Solar Energy, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, China.ORCID 0000-0003-0381-2234 Linqi WangState Key Laboratory of Microbial Diversity and Innovative Utilization, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.ORCID 0000-0002-5243-341X Xiao LiuState Key Laboratory of Microbial Diversity and Innovative Utilization, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.ORCID 0000-0001-6053-132X Shi'an WangShandong Provincial Key Laboratory of Synthetic Biology, Key Laboratory of Photoelectric Conversion and Utilization of Solar Energy, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, China.ORCID 0000-0001-8323-4344 Funding
MOST | National Key Research and Development Program of China (NKPs) 2023YFA0914400NSF of China 32202223Strategic Priority Research Program of the Chinese Academy of Sciences XDC0110303
6 · The paper itselfAbstract
Sterols, lipids, and carotenoids are major metabolites that share common biosynthetic precursors and underpin key physiological processes in eukaryotes. Yet, how cells coordinate metabolic flux through these competing pathways to maintain homeostasis remains unclear. Here, we identify a conserved RING-type E3 ubiquitin ligase, PTR1, as a central regulatory hub that orchestrates the interplay among these pathways in the yeast
Indexed as
BasidiomycotaCarotenoidsFungal ProteinsLipid MetabolismSterolsUbiquitin-Protein LigasesUbiquitinationXanthophyllsastaxanthineCarotenoidsFungal ProteinsSterolsUbiquitin-Protein LigasesXanthophyllscarotenoidE3 ubiquitin ligaselipidmetabolic regulationsterol
Identifiers
PMID42030148
PMCPMC13123865
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