Evidence map›Paper›PMID 42030022›Full record

ArticleBulletin of experimental biology and medicine2026

Human Multipotent Mesenchymal Stromal Cells Exhibit Resistance to Long-Term Simulated Microgravity.

E A Tyrina, I V Andrianova, E R Andreeva, Yu A Romanov, L B Buravkova

Abstract read
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Article in Bulletin of experimental biology and medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

E A TyrinaInstitute of Biomedical Problems, Russian Academy of Sciences, Moscow, Russia. eagolikovamsu@gmail.com.
I V AndrianovaInstitute of Biomedical Problems, Russian Academy of Sciences, Moscow, Russia.
E R AndreevaInstitute of Biomedical Problems, Russian Academy of Sciences, Moscow, Russia.
Yu A RomanovNational Medical Research Center of Cardiology Named after Academician E. I. Chazov, Ministry of Health of the Russian Federation, Moscow, Russia.
L B BuravkovaInstitute of Biomedical Problems, Russian Academy of Sciences, Moscow, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We performed a comprehensive analysis of changes in the functional state of human multipotent mesenchymal stromal cells derived from the umbilical cord tissue (UC-MSCs) after a 30-day simulated microgravity exposure. It was found that simulated microgravity induced changes in the expression of stromal markers and cell cycle regulators in UC-MSCs but did not alter their viability and expression of the cytoskeletal genes. We also observed shifts in the expression of adhesion molecules and enhanced secretion of proinflammatory cytokines. These findings indicate that microgravity modulates functional properties of MSCs and confirm the possibility of using these cells as a model system for studies of the molecular and cellular mechanisms underlying adaptation to microgravity during long-term spaceflights.

Indexed as

Mesenchymal Stem CellsWeightlessness SimulationCell Adhesion MoleculesCell DifferentiationCells, CulturedCell SurvivalCytokinesHumansUmbilical CordWeightlessnessCell Adhesion MoleculesCytokinessimulated microgravity (SMG)umbilical cord tissue-derived mesenchymal stromal cells (UC-MSCs)

Identifiers

PMID42030022

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.