Evidence map›Paper›PMID 42030012›Full record

ReviewStress biology2026

Exploiting plant immune "switches" for resistance engineering.

Bangting Wu, Kaichen Xu, Anum Bashir, Xinyu Han, Qiping Sun, Peng Sun, Guan-Feng Wang, Ricky J Milne, Meixiang Zhang, Leiyun Yang and 2 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Stress biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Bangting WuNational Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, Hubei Key Laboratory of Plant Pathology, The Center of Crop Nanobiotechnology, Huazhong Agricultural University, Wuhan, 430070, China.
Kaichen XuNational Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, Hubei Key Laboratory of Plant Pathology, The Center of Crop Nanobiotechnology, Huazhong Agricultural University, Wuhan, 430070, China.
Anum BashirNational Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, Hubei Key Laboratory of Plant Pathology, The Center of Crop Nanobiotechnology, Huazhong Agricultural University, Wuhan, 430070, China.
Xinyu HanNational Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, Hubei Key Laboratory of Plant Pathology, The Center of Crop Nanobiotechnology, Huazhong Agricultural University, Wuhan, 430070, China.
Qiping SunNational Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, Hubei Key Laboratory of Plant Pathology, The Center of Crop Nanobiotechnology, Huazhong Agricultural University, Wuhan, 430070, China.
Peng SunNational Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, Hubei Key Laboratory of Plant Pathology, The Center of Crop Nanobiotechnology, Huazhong Agricultural University, Wuhan, 430070, China.
Guan-Feng WangThe Key Laboratory of Plant Development and Environmental Adaptation Biology, Ministry of Education, School of Life Sciences, Shandong University, Qingdao, 266237, Shandong, China.
Ricky J MilneCSIRO Agriculture and Food, Canberra, ACT, 2601, Australia.
Meixiang ZhangCollege of Life Sciences, Shaanxi Normal University, Xian, 710119, China.
Leiyun YangState Key Laboratory of Agricultural and Forestry Biosecurity, College of Plant Protection, Nanjing Agricultural University, Nanjing, 210095, China.
Guoyong XuState Key Laboratory of Hybrid Rice, Institute for Advanced Studies (IAS), Hubei Hongshan Laboratory, RNA Institute, Wuhan University, Wuhan, 430072, China.
Guotian LiNational Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, Hubei Key Laboratory of Plant Pathology, The Center of Crop Nanobiotechnology, Huazhong Agricultural University, Wuhan, 430070, China. leeguotian@163.com.

Funding

Fundamental Research Funds for the Central Universities 2662024ZKPY001Fundamental Research Funds for the Central Universities 2662025ZKPY008Fundamental Research Funds for the Central Universities AML2023A05Gates Foundation INV-004428Key R&D Program of Hubei Province 2023BBB171National Key R&D Program of China 2022YFA1304402National Natural Science Foundation of China 32402323National Natural Science Foundation of China 32502447National Natural Science Foundation of China 32525050
6 · The paper itself

Abstract

Plant diseases, caused by various pathogens, pose a serious threat to sustainable agriculture. Plants have evolved a sophisticated immune system to detect and mount effective responses against pathogens. The plant immune system contains numerous programmable immune "switches" that safeguard plants against pathogens while minimizing energy consumption in the absence of pathogens. The cloning of disease-resistance (R) genes, along with the elucidation of the molecular mechanisms regulating these immune "switches", has provided resources and strategies for genetic engineering of novel disease resistance. This review focuses on the resistance engineering through the manipulation of immune "switches". It begins by summarizing recent advances in plant immunity, then explores the mechanisms behind plant immune "switches", and finally discusses potential strategies for engineering immune genes via these "switches". These strategies include engineering promoters to confer precise spatiotemporal regulation at the transcriptional level; engineering mRNA or its regulatory elements to facilitate specific and stable translation of R proteins at the post-transcriptional and translational levels; and engineering proteins at the post-translational level to broaden the pathogen-recognition spectrum of R proteins. Collectively, these strategies will accelerate the development of disease-resistant crop cultivars, thereby enhancing agricultural productivity and global food security.

Indexed as

Engineering mRNAEngineering promotersEngineering proteinsImmune “switches”Resistance engineering

Identifiers

PMID42030012
PMCPMC13109558

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.