Effects of dietary phytic acid on growth, antioxidant status, hepatic metabolism, and immune-related gene expression in Nile tilapia (Oreochromis niloticus).

Huai Zhang, Qifeng Lu, Jianwen Deng, Li Lin, Qingqing Li

Abstract read

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Article in Fish physiology and biochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

5 authors.

Huai ZhangGuangdong Provincial Water Environment and Aquatic Products Security Engineering Technology Research Center, Guangzhou Key Laboratory of Aquatic Animal Diseases and Waterfowl Breeding, College of Animal Sciences and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, 510225, Guangdong Province, China.

Qifeng LuGuangdong Provincial Water Environment and Aquatic Products Security Engineering Technology Research Center, Guangzhou Key Laboratory of Aquatic Animal Diseases and Waterfowl Breeding, College of Animal Sciences and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, 510225, Guangdong Province, China.

Jianwen DengGuangdong Provincial Water Environment and Aquatic Products Security Engineering Technology Research Center, Guangzhou Key Laboratory of Aquatic Animal Diseases and Waterfowl Breeding, College of Animal Sciences and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, 510225, Guangdong Province, China.

Li LinGuangdong Provincial Water Environment and Aquatic Products Security Engineering Technology Research Center, Guangzhou Key Laboratory of Aquatic Animal Diseases and Waterfowl Breeding, College of Animal Sciences and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, 510225, Guangdong Province, China. linli@zhku.edu.cn.

Qingqing LiGuangdong Provincial Water Environment and Aquatic Products Security Engineering Technology Research Center, Guangzhou Key Laboratory of Aquatic Animal Diseases and Waterfowl Breeding, College of Animal Sciences and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, 510225, Guangdong Province, China. liqingqing@zhku.edu.cn.

Funding

Guangdong Province Commissioner for Rural Science and Technology in Towns and Village KTP20240129Guangzhou Science and Technology Plan Project 2024A04J4999

6 · The paper itself

Abstract

Phytic acid (PA) is a common anti-nutritional factor in plant-based aquafeeds that can affect nutrient utilization and physiological homeostasis in fish. However, its dose-dependent physiological effects on Nile tilapia (Oreochromis niloticus) remain poorly characterized. This study investigated the effects of graded dietary levels of PA (0, 10, 15, 20, and 25 g/kg) on growth performance, antioxidant status, hepatic metabolism, and immune regulation in Nile tilapia. Results showed that dietary PA significantly reduced body weight gain and increased liver somatic index in a dose-dependent manner. Antioxidant capacity was impaired, hepatic function was disrupted, and immune-related gene expression was altered. No significant differences were observed in survival rate among treatments. Collectively, these findings demonstrate that excessive dietary PA induces metabolic stress in Nile tilapia, characterized by oxidative imbalance, hepatic dysfunction, and immune dysregulation. These results highlight the importance of controlling PA levels or applying targeted mitigation strategies in aquafeed formulations to maintain fish health and optimize aquaculture productivity.

Indexed as

AntioxidantsCichlidsLiverPhytic AcidAnimal FeedAnimalsDietDose-Response Relationship, DrugGene Expression RegulationOxidative StressAntioxidantsPhytic AcidHepatic injuryImmune dysregulationOreochromis niloticusOxidative stressPhytic acid

Identifiers

PMID42029770

DOI10.1007/s10695-026-01688-y

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.