ArticleFish physiology and biochemistry2026
Feeding and light cycle disruptions have distinct effects on energy balance and neuroendocrine regulators in goldfish.
Article in Fish physiology and biochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
The synchronization of biological rhythms to environmental cues is essential for maintaining temporal homeostasis. However, the specific neuroendocrine and metabolic effects of circadian misalignment in fish remain poorly understood. This study investigated the effects of chronodisruption on energy homeostasis in goldfish (Carassius auratus). Fish were exposed for 53 days to three conditions: Control (12L:12D photoperiod, feeding at ZT 1); Random Feeding (RF; 12L:12D, feeding at random times) and continuous light (LL, feeding at ZT 1). Feed intake, metabolic rate, and locomotor activity were monitored as indicators of energy input and expenditure. Biometric indices (weight and length gain, growth, nutritional and hepatosomatic indices) were calculated. The expression of feeding and growth regulating genes was also analyzed in hypothalamus (hcrt, npy, crh, pomca, cartpt1, and cartpt2), telencephalon (cnr1), liver (igf1, and lepa1), and intestine (cck1 and ghrl). Plasma and liver metabolites (triglycerides, glycogen, lactate, and glucose) and plasma cortisol levels were analyzed to assess metabolic and stress responses. Both RF and LL groups showed elevated metabolic rate and feed intake, accompanied by changes in the expression of feeding regulators that favored orexigenic signals. However, only RF fish showed increased growth, weight, hepatosomatic index, and plasma glucose, suggesting a positive energy balance. LL fish showed growth similar to controls, likely due to a greater increase in energy expenditure. Overall, our results show that disruption of temporal feeding or light cues alters energy balance, with different physiological outcomes depending on the type of disruption. This study highlights the critical role of circadian alignment in maintaining energy homeostasis in goldfish.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.