Evidence map›Paper›PMID 42029746›Full record

ArticleActa neuropathologica2026

Altered astrocyte-neuron crosstalk in progressive supranuclear palsy: integrated evidence from proteomics and magnetic resonance spectroscopy.

Maiko Ono, Yuta Kumagai, Kosei Hirata, Yuki Maeda, Yurika Abe, Hironobu Endo, Hiroshi Shimizu, Akiyoshi Kakita, Yasuo Uchida, Yuhei Takado

Abstract read
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In one paragraph

Article in Acta neuropathologica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Maiko OnoInstitute for Quantum Life Science, National Institutes for Quantum Science and Technology (QST), 4-9-1 Anagawa, Inage-ku, Chiba-shi, Chiba, 263-8555, Japan. ono.maiko@qst.go.jp.
Yuta KumagaiFaculty of Pharmaceutical Sciences, Hiroshima University, Hiroshima, Japan.
Kosei HirataInstitute for Quantum Life Science, National Institutes for Quantum Science and Technology (QST), 4-9-1 Anagawa, Inage-ku, Chiba-shi, Chiba, 263-8555, Japan.
Yuki MaedaGraduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Yurika AbeGraduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.
Hironobu EndoAdvanced Neuroimaging Center, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, Chiba, Japan.
Hiroshi ShimizuDepartment of Pathology, Brain Research Institute, and The Center for Human Brain Resource Initiative, Niigata University, Niigata, Japan.
Akiyoshi KakitaDepartment of Pathology, Brain Research Institute, and The Center for Human Brain Resource Initiative, Niigata University, Niigata, Japan.
Yasuo UchidaFaculty of Pharmaceutical Sciences, Hiroshima University, Hiroshima, Japan.
Yuhei TakadoInstitute for Quantum Life Science, National Institutes for Quantum Science and Technology (QST), 4-9-1 Anagawa, Inage-ku, Chiba-shi, Chiba, 263-8555, Japan. takado.yuhei@qst.go.jp.

Funding

Japan Agency for Medical Research and Development JP24dk0207063Japan Agency for Medical Research and Development JP25wm0625126Japan Society for the Promotion of Science JPJS00420240016Japan Society for the Promotion of Science JPJSJRP20221510Japan Society for the Promotion of Science London JP25K10974Ministry of Education, Culture, Sports, Science and Technology JPMXP1323015488
6 · The paper itself

Abstract

The anterior cingulate cortex (ACC), crucial for executive function, is frequently impaired in progressive supranuclear palsy (PSP), yet mechanisms underlying this selective vulnerability remain unclear. Given the integration of astrocytes into neural circuits, we hypothesized that astrocyte dysfunction and altered astrocyte-neuron crosstalk contribute to functional abnormalities in the ACC in PSP. To test this hypothesis, we conducted a multimodal analysis integrating SWATH-MS-based proteomics, histopathology, and in vivo magnetic resonance spectroscopy (MRS) in postmortem and living brains of patients with PSP and healthy controls (HCs). The astrocytic markers glial fibrillary acidic protein (GFAP) and aquaporin-4 (AQP4) were significantly elevated in the ACC of patients with PSP compared with those in HCs. Enhanced astrocytic Ca

Indexed as

AstrocytesNeuronsSupranuclear Palsy, ProgressiveAgedAged, 80 and overAquaporin 4FemaleGlial Fibrillary Acidic ProteinHumansMagnetic Resonance SpectroscopyMaleMiddle AgedProteomicsAquaporin 4Glial Fibrillary Acidic ProteinAstrocyte–neuron crosstalkE/I balanceEnergy metabolismGlymphatic systemProgressive supranuclear palsy

Identifiers

PMID42029746

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.