ArticleAnnals of medicine2026
Performance of the AUB-HAS2 cardiovascular risk index in coronary artery disease: a multicenter retrospective cohort study.
Article in Annals of medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundWhile the American University of Beirut (AUB)-HAS2 cardiovascular risk index has emerged as a novel tool for preoperative risk stratification, its performance specifically in coronary artery disease (CAD) patients warrants further validation. This study aimed to evaluate the performance of AUB-HAS2 index specifically in CAD patients.
methodsIn this multicenter retrospective cohort study, we enrolled consecutive adult patients with documented CAD who underwent non-cardiac surgery between 2013 and 2024 at two tertiary academic medical centers in Zhejiang, China. The primary outcome was a composite of perioperative cardiovascular events (PCE), including all-cause death, myocardial infarction, or stroke, occurring intraoperatively or during postoperative hospitalization.
resultsAmong 10,294 participants, 374 (3.6%) experienced PCEs. The incidence of PCEs increased steadily with the increase in AUB-HAS2 index (0.3%, 2.3%, 5.2%, 10.1%, and 21.7% for AUB-HAS2 index of 0, 1, 2, 3, and > 3, respectively; p value for trend < 0.001). The AUB-HAS2 index showed significantly better discrimination than the revised cardiac risk index (RCRI) (C-statistic: 0.765 vs. 0.689;
conclusionsThe AUB-HAS2 index demonstrates improved predictive performance compared to the RCRI in CAD patients, supporting its clinical adoption for preoperative cardiovascular risk stratification in this high-risk population.
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