Evidence map›Paper›PMID 42029424›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Life course neighborhood conditions and change: a 20-year examination of neighborhood context and associations with Alzheimer's disease biomarkers in late life.

Alexandra L Clark, Abbey M Hamlin

Abstract read
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In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Alexandra L ClarkDepartment of Psychology, The University of Texas at Austin, Austin, Texas, USA.ORCID 0000-0002-7437-5409
Abbey M HamlinDepartment of Psychology, The University of Texas at Austin, Austin, Texas, USA.

Funding

Program Development and Pilot CoreP30AG066614 · NIA · UNIVERSITY OF TEXAS AT AUSTIN · PI KAREN L FINGERMAN · 2020 to 2026
$5.2M
The impact of segregation and the mediating effects of vascular risk on 10-year cognitive and functional outcomes in Black/African American older adults enrolled in the ACTIVE studyR03AG085241 · NIA · UNIVERSITY OF TEXAS AT AUSTIN · PI CLARK, ALEXANDRA LEIGH, MARSISKE, MICHAEL · 2023 to 2023
$329k
Center on Aging and Population Sciences at The University of Texas at Austin P30AG066614National Science Foundation Graduate Research Fellowship Program DGE-2137420NIA NIH HHS P30 AG066614NIA NIH HHS R03 AG085241
6 · The paper itself

Abstract

introductionLife course models of Alzheimer's disease (AD) suggest that both long-term exposure to neighborhood conditions and changes in neighborhood context may shape dementia risk. This study examined the impact of mid- and late-life levels of neighborhood segregation, as well as longitudinal change in segregation, on plasma AD biomarkers.

methodsParticipants were 119 racially/ethnically diverse (60% Black/Latino) adults. Residential addresses were geocoded to temporally harmonized US Census tracts, and the dissimilarity index quantified segregation. Plasma neurofilament light chain (NfL), glial fibrillary acidic protein (GFAP), and amyloid beta (Aβ) 42/40 were measured.

resultsGeneralized estimating equations adjusting for individual-level sociodemographic and health characteristics revealed mid-life, but not late-life, levels of segregation were significantly associated with NfL. Increasing segregation across 10- and 20-year periods was associated with higher levels of GFAP and NfL, respectively. DISCUSSION: Mid-life levels of segregation and longitudinal change in segregation were linked to plasma markers of neurodegeneration and astroglial activation.

Indexed as

Alzheimer DiseaseNeighborhood CharacteristicsResidence CharacteristicsAgedAged, 80 and overAmyloid beta-PeptidesBiomarkersFemaleGlial Fibrillary Acidic ProteinHumansLongitudinal StudiesMaleMiddle AgedNeurofilament ProteinsPeptide FragmentsResidential SegregationAmyloid beta-Peptidesamyloid beta-protein (1-40)amyloid beta-protein (1-42)BiomarkersGFAP protein, humanGlial Fibrillary Acidic Proteinneurofilament protein LNeurofilament ProteinsPeptide Fragmentsexposomelife course approach to Alzheimer's diseaselife course theoryneighborhood changeresidential racial segregation

Identifiers

PMID42029424
PMCPMC13108247

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.