Evidence map›Paper›PMID 42029421›Full record

ArticleJournal of cosmetic dermatology2026

Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Preserve Melanocyte Stem Cell Integrity Under Acute Neurogenic Oxidative Stress via Activation of the Nrf2-ARE Pathway in C57BL/6J Mice.

Jingbo Cui, Linxia Duan, Hui Qu, Jing Ning, Zhi Li, Huihua Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cosmetic dermatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jingbo CuiShanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, China.
Linxia DuanShanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, China.
Hui QuShanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, China.
Jing NingShanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, China.
Zhi LiShanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, China.
Huihua ZhangShanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, China.ORCID https://orcid.org/0009-0004-2231-7372

Funding

Shanxi Basic Research Program Free Exploration Category Project 202303021222317
6 · The paper itself

Abstract

backgroundStress-induced hair depigmentation is closely associated with neurogenic oxidative stress and dysfunction of melanocyte stem cells. Activation of antioxidant defense pathways, particularly the Nrf2-ARE pathway, may protect melanocytes from oxidative damage.

aimsTo investigate whether exosomes derived from human umbilical cord mesenchymal stem cells (HUCB-MSC-Exo) preserve melanocyte stem cell integrity under acute neurogenic oxidative stress through activation of the Nrf2-ARE pathway. PATIENTS/

methodsHUCB-MSC-Exo were characterized by transmission electron microscopy and the expression of exosomal markers CD63 and CD81. Melan-a cells were treated with exosomes at concentrations ranging from 0.50 × 10

resultsHUCB-MSC-Exo promoted Melan-a cell proliferation in a dose-dependent manner, with increases of 53% and 94% at 1.5 × 10

conclusionsHUCB-MSC-Exo alleviates acute neurogenic oxidative stress and preserves melanocyte function by activating the Nrf2-ARE pathway, thereby mitigating stress-induced hair depigmentation in C57BL/6J mice.

Indexed as

ExosomesMelanocytesMesenchymal Stem CellsNF-E2-Related Factor 2Oxidative StressAnimalsAntioxidant Response ElementsCell ProliferationCells, CulturedFemaleHair FollicleHumansMiceMice, Inbred C57BLSignal TransductionUmbilical CordNFE2L2 protein, humanNfe2l2 protein, mouseNF-E2-Related Factor 2ExosomeHair folliclesHair grayingNrf2‐ARE pathwayResinferation

Identifiers

PMID42029421
PMCPMC13108552

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.