Evidence map›Paper›PMID 42029420›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Visual memory correlates with AD biomarkers in cognitively unimpaired individuals.

Taylor A James, Liping Zhao, Han Xu, Junjie Wu, David A Schweidel, Felicia C Goldstein, Allan I Levey, Deqiang Qiu, David W Loring, John J Hanfelt and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Taylor A JamesDepartment of Neurology, Emory University School of Medicine, Atlanta, Georgia, USA.ORCID 0000-0002-7038-851X
Liping ZhaoEmory Goizueta Alzheimer's Disease Research Center, Emory University, Atlanta, Georgia, USA.
Han XuEmory Goizueta Alzheimer's Disease Research Center, Emory University, Atlanta, Georgia, USA.
Junjie WuDepartment of Neurology, Emory University School of Medicine, Atlanta, Georgia, USA.
David A SchweidelGoizueta Business School, Emory University, Atlanta, Georgia, USA.
Felicia C GoldsteinDepartment of Neurology, Emory University School of Medicine, Atlanta, Georgia, USA.
Allan I LeveyDepartment of Neurology, Emory University School of Medicine, Atlanta, Georgia, USA.
Deqiang QiuEmory Goizueta Alzheimer's Disease Research Center, Emory University, Atlanta, Georgia, USA.
David W LoringDepartment of Neurology, Emory University School of Medicine, Atlanta, Georgia, USA.
John J HanfeltEmory Goizueta Alzheimer's Disease Research Center, Emory University, Atlanta, Georgia, USA.
James J LahDepartment of Neurology, Emory University School of Medicine, Atlanta, Georgia, USA.

Funding

The Emory Healthy Brain Study: Discovering Predictive Biomarkers for Alzheimer's DiseaseR01AG070937 · NIA · EMORY UNIVERSITY · PI LAH, JAMES J · 2021 to 2025
$35.2M
NIA NIH HHS R01 AG070937NIA NIH HHS R01-AG070937Roche Diagnostics IIS RD004723
6 · The paper itself

Abstract

introductionAlzheimer's disease (AD) pathology evolves silently for many years prior to disease, and early identification of individuals at greatest risk is critical for improving outcomes.

methodsWe conducted exploratory factor analysis (EFA) using neuropsychological testing of 1697 healthy adults. Factor scores were submitted as predictors for structural magnetic resonance imaging, functional connectivity, and cerebrospinal fluid (CSF) biomarkers.

resultsThe EFA model identified five latent factors. Factor 1, Verbal Memory, included high loadings from Rey Auditory Verbal Learning Test, and Factor 2, Visual Memory, included high loadings from Rey Complex Figure Test (RCFT). Factor 2 positively correlated with hippocampal volume, precuneus and posterior salience network connectivity, and negatively with CSF tau. Factor 1 correlated with hippocampal volume but not with network connectivity or CSF biomarkers. DISCUSSION: Results demonstrate a significant relationship of visual memory with AD biomarkers. RCFT may be an important assessment for evaluating and tracking individuals during the earliest stages of AD pathology.

Indexed as

Alzheimer DiseaseBrainMemoryVisual PerceptionAdultAgedBiomarkersFactor Analysis, StatisticalFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedNeuropsychological Teststau ProteinsBiomarkerstau ProteinsagingAlzheimer's diseasebiomarkerscerebrospinal fluidEmory Healthy Brain Studyexploratory factor analysisfunctional brain networksmagnetic resonance imagingneuropsychologicalvisual memory

Identifiers

PMID42029420
PMCPMC13108244

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.