Evidence map›Paper›PMID 42029411›Full record

ArticleChemistry & biodiversity2026

Investigating the Chemical, Antifungal, and Cytotoxic Properties of Cochlospermum vitifolium Leaves and Stem Bark Extracts.

Francisco A S D Pinheiro, Addison R Almeida, Matheus S Menezes, Thomaz Rocha, Weslley S Paiva, Hugo A O Rocha, Cristiane F de Assis, Gislene Ganade, Laila S Espindola, Leandro S Ferreira

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Francisco A S D PinheiroPrograma de Pós-Graduação em Ciências Farmacêuticas, Departamento de Farmácia, Universidade Federal do Rio Grande Do Norte (UFRN), Natal, Brazil.
Addison R AlmeidaDepartamento de Farmácia, Universidade Federal do Rio Grande Do Norte (UFRN), Natal, Brazil.
Matheus S MenezesPrograma de Pós-Graduação em Ciências Farmacêuticas, Departamento de Farmácia, Universidade Federal do Rio Grande Do Norte (UFRN), Natal, Brazil.
Thomaz RochaPrograma de Pós-Graduação em Ecologia, Departamento de Ecologia, Centro de Biociências, Universidade Federal do Rio Grande Do Norte (UFRN), Natal, Brazil.
Weslley S PaivaLaboratório de Biotecnologia de Polímeros Naturais-BIOPOL, Departamento de Bioquímica, Universidade Federal do Rio Grande Do Norte (UFRN), Natal, Brazil.
Hugo A O RochaLaboratório de Biotecnologia de Polímeros Naturais-BIOPOL, Departamento de Bioquímica, Universidade Federal do Rio Grande Do Norte (UFRN), Natal, Brazil.
Cristiane F de AssisDepartamento de Farmácia, Universidade Federal do Rio Grande Do Norte (UFRN), Natal, Brazil.
Gislene GanadePrograma de Pós-Graduação em Ecologia, Departamento de Ecologia, Centro de Biociências, Universidade Federal do Rio Grande Do Norte (UFRN), Natal, Brazil.
Laila S EspindolaLaboratório de Farmacognosia, Campus Universitário Darcy Ribeiro, Universidade de Brasília, Brasília, Brazil.
Leandro S FerreiraPrograma de Pós-Graduação em Ciências Farmacêuticas, Departamento de Farmácia, Universidade Federal do Rio Grande Do Norte (UFRN), Natal, Brazil.ORCID https://orcid.org/0000-0002-8408-5886

Funding

Associação CaatingaCNPq 001CNPq 311248/2025-0Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 001Fundação de Amparo à Pesquisa do Distrito Federal 542/2023
6 · The paper itself

Abstract

Comprehensive analysis of the chemical properties and bioactivities of plant extracts is essential for identifying compounds with therapeutic potential. This study analyzed hydroethanolic extracts from the leaves and stem bark of Cochlospermum vitifolium, investigating their chemical composition, antifungal, and cytotoxic activity. UHPLC-MS/MS, GC-MS and bioinformatic tools techniques were employed to characterize the chemical profiles. Antioxidant activities were evaluated using DPPH and ABTS assays, cytotoxicity assessed in L929 fibroblasts and MC3T3 osteoblast-like cells, and antifungal activity was evaluated against Candida spp. The leaf extract exhibited higher total phenolic and flavonoid content, antioxidant capacity in both radical-scavenging, and antifungal activity, reaching a minimum inhibitory concentration of 1.95 µg/mL against Candida albicans. None of the extracts showed cytotoxicity. PCA, chord diagram, and volcano plot indicated clear differences between the chemical profiles of the leaves and stem bark and supported the association between these metabolites and the observed antifungal activity. Finally, in vitro antifungal tests were performed for the first time with C. vitifolium, showing promising results against Candida spp. species, suggesting a safe alternative as an antifungal agent.

Indexed as

Antifungal AgentsPlant ExtractsAnimalsAntioxidantsBenzothiazolesBiphenyl CompoundsCandida albicansCell LineCell SurvivalMiceMicrobial Sensitivity TestsPicratesPlant BarkPlant LeavesPlant StemsAntifungal AgentsAntioxidantsBenzothiazolesBiphenyl CompoundsPicratesPlant Extractsantifungalchemical profileCochlospermum vitifoliumcytotoxicityleaves extractstem bark extract

Identifiers

PMID42029411
PMCPMC13108566

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.