Evidence map›Paper›PMID 42029369›Full record

ArticleJACC. Clinical electrophysiology2026

Sinoatrial Node Impulses Emerge From Unique Synchronization Processing Solutions of Partially Stochastic Local Calcium Signals.

Syevda Tagirova, Alexander V Maltsev, Georgiana L Baca, Victor A Maltsev, Rostislav Bychkov, Edward G Lakatta

Abstract read
In one paragraph

Article in JACC. Clinical electrophysiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Syevda TagirovaLaboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA. Electronic address: syevda.tagirova@nih.gov.
Alexander V MaltsevLaboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA.
Georgiana L BacaLaboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA.
Victor A MaltsevLaboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA.
Rostislav BychkovLaboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA.
Edward G LakattaLaboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA. Electronic address: LakattaE@mail.nih.gov.

Funding

Intramural NIH HHS Z99 AG999999
6 · The paper itself

Abstract

backgroundIncessant, spontaneous, heterogeneous local calcium (Ca

objectivesThe goal of this study was to define how LCO information processing forms recurrent, rhythmic global SAN impulses.

methodsNovel dynamical systems and network analyses were applied to images of Ca

resultsCa

conclusionsThis novel paradigm for SAN impulse formation provides flexibility and reliability for heartbeat regulation that will enhance understanding of SAN autonomic regulation, arrhythmogenesis, and sick sinus syndrome.

Indexed as

Calcium SignalingSinoatrial NodeAction PotentialsAnimalsCalciumMiceStochastic ProcessesCalciumcardiac sinoatrial node pacemaker functionnetwork of functional calcium signaling clusterspartially stochastic nonlinear calcium dynamicssmall-world information flow signaling

Identifiers

PMID42029369
PMCPMC13250805

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.