ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026
Infection of 5xFAD mice with a mouse-adapted SARS-CoV-2 does not alter Alzheimer's disease neuropathology yet induces widespread changes in gene expression across diverse cell types.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionThe COVID-19 pandemic underscored the impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on worsening the severity of Alzheimer's disease (AD) neuropathology and disease progression.
methodsAged 5xFAD and wild-type (WT) mice were infected with a mouse-adapted SARS-CoV-2 (MA10), and extensive characterization of molecular and cellular changes within the brains was carried out.
resultsMA10 infection induced acute viral pneumonia. Viral RNA was undetectable within the brains of infected mice, and there was no evidence of glial activation or neuroinflammation. MA10 infection did not affect amyloid beta (Aβ) plaque volume or numbers in 5xFAD mice compared to uninfected mice. Spatial transcriptomics revealed altered expression of genes associated with homeostatic function in neurons, glia, and vascular endothelial cells. DISCUSSION: Collectively, these findings demonstrate that while MA10 infection did not affect AD neuropathology, there were numerous downstream effects on gene expression associated with resident central nervous system cell functions that may impact neurologic disease.
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