Evidence map›Paper›PMID 42028993›Full record

ArticleJournal of veterinary pharmacology and therapeutics2026

Influence of Tramadol on the Intravenous Pharmacokinetics of Dipyrone Active Metabolites in Dogs.

Andressa Nunes Mouta, Kathryn Nóbrega Arcoverde, Robson Dos Anjos Honorato, Naftáli Silva Fernandes, Caio Vinicius Almeida de Oliveira, Glícia Cavalcante Mesquita, Yanna Deysi Bandeira Passos, Gabriel Araújo-Silva, Valéria Veras de Paula

Abstract read
In one paragraph

Article in Journal of veterinary pharmacology and therapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Andressa Nunes MoutaDepartamento de Ciência Animal, Universidade Federal Rural Do Semi-Árido (UFERSA), Mossoró, Brazil.ORCID https://orcid.org/0000-0003-0319-2696
Kathryn Nóbrega ArcoverdeDepartamento de Ciência Animal, Universidade Federal Rural Do Semi-Árido (UFERSA), Mossoró, Brazil.
Robson Dos Anjos HonoratoCentro Universitário INTA - UNINTA, Rua Antônio Rodrigues Magalhães, 359, Dom Expedito Lopes, Sobral, Brazil.
Naftáli Silva FernandesDepartamento de Ciência Animal, Universidade Federal Rural Do Semi-Árido (UFERSA), Mossoró, Brazil.
Caio Vinicius Almeida de OliveiraDepartamento de Ciência Animal, Universidade Federal Rural Do Semi-Árido (UFERSA), Mossoró, Brazil.
Glícia Cavalcante MesquitaDepartamento de Ciência Animal, Universidade Federal Rural Do Semi-Árido (UFERSA), Mossoró, Brazil.
Yanna Deysi Bandeira PassosDepartamento de Ciência Animal, Universidade Federal Rural Do Semi-Árido (UFERSA), Mossoró, Brazil.
Gabriel Araújo-SilvaEscola de Química, Universidade Do Estado Do Amapá, Avenida Presidente Vargas, Centro, Macapá, Brazil.ORCID https://orcid.org/0000-0002-9073-1995
Valéria Veras de PaulaDepartamento de Ciência Animal, Universidade Federal Rural Do Semi-Árido (UFERSA), Mossoró, Brazil.ORCID https://orcid.org/0000-0003-4292-4861

Funding

National Council for Scientific and Technological Development 403419/2023-9
6 · The paper itself

Abstract

This study aimed to compare the pharmacokinetic profile of the active dipyrone metabolites 4-methylaminoantipyrine (MAA) and 4-aminoantipyrine (AA) administered alone and in combination with tramadol in dogs. Nine mixed-breed dogs, weighing 15.33 ± 2.25 kg, participated in a two-treatment crossover design: G1 received intravenous dipyrone (25 mg kg

Indexed as

Analgesics, OpioidAnti-Inflammatory Agents, Non-SteroidalDipyroneTramadolAmpyroneAnimalsArea Under CurveCross-Over StudiesDogsDrug InteractionsFemaleHalf-LifeMaleAmpyroneAnalgesics, OpioidAnti-Inflammatory Agents, Non-SteroidalDipyroneTramadol4‐aminoantipyrine4‐methylaminoantipyrinemetamizoleN‐desmethyltramadolO‐desmethyltramadol

Identifiers

PMID42028993
PMCPMC13552518

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.