Evidence map›Paper›PMID 42028950›Full record

ArticleBalkan medical journal2026

Shidong Zuo, Jinkai Dong, Yuhao Dong, Chengwei Fu, Xuechao Li, Baobo Zhao, Lu Wang, Yongjie Zhang, Lingsheng Kong, Tao Yang and 1 more

Abstract read
In one paragraph

Article in Balkan medical journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Shidong ZuoMedical School of Chinese PLA: Chinese PLA General Hospital, Beijing, China.ORCID 0009-0003-0570-7099
Jinkai DongDepartment of Urology, The Third Medical Center, Chinese PLA General Hospital, Beijing, China.ORCID 0009-0004-9486-2273
Yuhao DongMedical School of Chinese PLA: Chinese PLA General Hospital, Beijing, China.ORCID 0009-0009-2017-6314
Chengwei FuDepartment of Urology, The Third Medical Center, Chinese PLA General Hospital, Beijing, China.ORCID 0009-0009-7994-8710
Xuechao LiDepartment of Urology, The Third Medical Center, Chinese PLA General Hospital, Beijing, China.ORCID 0009-0007-7317-1694
Baobo ZhaoDepartment of Urology, The Third Medical Center, Chinese PLA General Hospital, Beijing, China.ORCID 0009-0002-4231-4123
Lu WangDepartment of Obstetrics and Gynecology, The Seventh Medical Center, Chinese PLA General Hospital, Beijing, China.ORCID 0009-0000-3384-9594
Yongjie ZhangDepartment of Urology, Peking University People's Hospital, Beijing, China.ORCID 0009-0006-5557-1160
Lingsheng KongDepartment of Urology, The Third Medical Center, Chinese PLA General Hospital, Beijing, China.ORCID 0009-0008-4137-7644
Tao YangDepartment of Urology, The Third Medical Center, Chinese PLA General Hospital, Beijing, China.ORCID 0009-0007-3572-7049
Lijun ChenMedical School of Chinese PLA: Chinese PLA General Hospital, Beijing, China.ORCID 0009-0008-1600-9882

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Extensive studies have implicated glycolytic reprogramming and lactate accumulation in immune evasion. However, clustered regularly interspaced short palindromic repeats (CRISPR)-based Aims: To identify key metabolic genes governing immune checkpoint blockade resistance in ccRCC via Study Design: Integrated in vivo CRISPR screening, functional assays, and clinical validation. Methods: A metabolic CRISPR library-based screen was conducted in an Results: Anti-PD-1 therapy selectively reduced sgRNA counts for glycolysis-lactate genes, most notably Ldha and Conclusion:

Indexed as

Carcinoma, Renal CellLactic AcidMonocarboxylic Acid TransportersAnimalsHumansKidney NeoplasmsMetabolic ReprogrammingMiceProto-Oncogene Proteins c-mycReceptors, G-Protein-CoupledHCAR1 protein, humanLactic AcidMonocarboxylic Acid TransportersProto-Oncogene Proteins c-mycReceptors, G-Protein-Coupled

Identifiers

PMID42028950
PMCPMC13424917

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.