ReviewThe Journal of physiology2026
Exercise in acute and subacute hypoxic conditions: physiological responses affecting oxygen delivery and their applications to human health.
Review in The Journal of physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Intermittent hypoxic conditioning as a novel strategy for obesity treatment: current evidence and future perspectives.Frontiers in physiology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Exercise at altitude is performed by a spectrum of individuals ranging from healthy to those with cardiovascular and pulmonary diseases. Reduced atmospheric oxygen pressure at increased altitude reduces oxygen availability and poses unique challenges during exercise. This review explores the physiological responses to exercise under acute and subacute exposure to hypoxia within the autonomic, pulmonary, cardiovascular and haematologic systems. In response to acutely reduced arterial pressure of oxygen, peripheral chemoreceptors stimulate centrally mediated reflexes including the hypoxic ventilatory response and increase sympathetic nerve-mediated activity to the peripheral vasculature and skeletal muscle. Additionally, reduced pressure of oxygen in the pulmonary alveoli and kidneys stimulate hypoxic pulmonary vasoconstriction and erythropoiesis, respectively. During acute hypoxic exercise, heart rate and minute ventilation are greater for any given workload, and maximal oxygen consumption is progressively reduced with increasing altitude. For individuals with cardiovascular and/or pulmonary diseases, exertional hypoxaemia and constraints related to the hypoxic ventilatory response and hypoxic pulmonary vasoconstriction further limit exercise at altitude and increase the risk of adverse events. Exercise in acute hypoxic conditions has been evaluated in patients with stable, mild-to-moderate cardiovascular and/or pulmonary diseases, where it is associated with anticipated decrements in exercise performance but appears to be largely tolerated. However, further study is required to counsel patients across a spectrum of disease severity. Finally, hypoxic exercise has been investigated in limited settings as a therapeutic intervention, including for overweight/obesity, right ventricular remodelling and ageing, but further research is needed to determine the potential roles for hypoxic exercise as therapy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.